Immunohistochemical Evaluation of Transforming Growth Factor-β Expression in Oral Lichen Planus
| Author | Narges Ghazi | en |
| Author | Nasrollah Saghravanian | en |
| Author | Ala Ghazi | en |
| Author | Mohammad Ghadirifard | en |
| Orcid | Narges Ghazi [0000-0002-7356-1509] | en |
| Orcid | Ala Ghazi [0000-0002-0064-1233] | en |
| Issued Date | 2021-12-31 | en |
| Abstract | Background: In oral lichen planus (OLP), which is a persistent inflammatory condition of the autoimmune system, cytotoxic T lymphocytes are triggered against epithelial cells. OLP resists treatment more than its cutaneous counterpart and potentially transforms into malignancy as oral squamous cell carcinoma (OSCC). Transforming growth factor β (TGF-β) is produced by various cells, such as leukocytes and epithelial cells, whereby epithelial-mesenchymal-epithelialn (EMT) forms the phenotype of invasive cancerous cells and promotes tumors. Objectives: We investigated the role of TGF-β in the pathogenesis and biological behavior of dysplastic and non-dysplastic OLP. Methods: Thirty samples of erosive/atrophic OLP (15 dysplastic and 15 non-dysplastic) and 10 samples of normal mucosa of the oral cavity were immunohistochemically examined for the expression of TGF-β. Statistical analysis was performed using the Kruskal-Wallis and chi-squared tests. Results: TGF-β expressed to varying degrees in the epithelium of the studied groups. The groups significantly differed in terms of the expression of TGF-β. In pairwise comparisons, the dysplastic OLP group showed significantly higher immunoreactivity than the normal and non-dysplastic groups, although there was no significant difference between the normal and non-dysplastic OLP groups. The expression of TGF-β in the sub-epithelial lymphocytes of the dysplastic and non-dysplastic OLP groups showed a statistically significant difference. Conclusions: According to the results, TGF-β, as a marker of the inflammatory process in chronic inflammatory conditions, was expressed in epithelial cells and sub-epithelial lymphocytes of all OLPs. This suggests a possible role of this marker in the pathogenesis of OLP. In addition, the increased expression of TGF-β, a marker also involved in carcinogenesis, in the epithelial keratinocytes indicates the role it might play in the development of carcinoma in OLP. | en |
| DOI | https://doi.org/10.5812/ijcm-116421 | en |
| Keyword | Oral Lichen Planus | en |
| Keyword | Immunohistochemistry | en |
| Keyword | TGF-β | en |
| Publisher | Brieflands | en |
| Title | Immunohistochemical Evaluation of Transforming Growth Factor-β Expression in Oral Lichen Planus | en |
| Type | Research Article | en |