Case Report of <i>Enterobacter cloacae</i> Producing IMP-8 Carbapenemase Isolated from Secretions of Burn Patients and Diabetes Patients with Diabetic Foot
| Author | Feng Pang | en |
| Author | Xiu-Qin Jia | en |
| Author | Qi-Gang Zhao | en |
| Author | Yi Zhang | en |
| Orcid | Xiu-Qin Jia [0000-0001-8309-3246] | en |
| Issued Date | 2017-12-31 | en |
| Abstract | Introduction: With the widespread use of cephalosporins, Enterobacter cloacae has become an increasingly important pathogen of nosocomial infections, which causes bacterial infectious diseases involving multiple organ systems. The presence of carbapenem-resistant strains has resulted in problems in the current clinical anti-infective treatment. The current study reports on four cases of carbapenem-resistant E. cloacae secretion infection in order to provide suggestions for the detection and treatment of these pathogen infections. Case Presentation: Investigation of 4 cases was conducted at tertiary care hospitals, and baseline data, treatment and outcomes were collected for patients with carbapenem-resistant E. cloacae infection. The strains of burn injury and diabetic foot infection were retrieved from specimens by culture-based methods, and antibiotic sensitivity test was conducted on Vitek 2. All strains showed minimum inhibitory concentration (MIC) values for ertapenem, imipenem, and meropenem of less than 4 μg/mL. The four strains of E. cloacae produced IMP-8 type carbapenemase confirmed by PCR and sequence analysis. After the selection of reasonable antibiotic treatment, the patient`s condition had improved and they were discharged from the hospital. Conclusions: Low MIC value makes it difficult to detect IMP-8-harboring strains by traditional susceptibility test; molecular biology techniques may be mandatory for detection of carbapenem resistant isolates. It is very important to treat patients with reasonable antimicrobial based on susceptibility results. | en |
| DOI | https://doi.org/10.5812/jjm.56006 | en |
| Keyword | IMP-8 Carbapenemase | en |
| Keyword | Secretion Infection | en |
| Keyword | <i>Enterobacter cloacae</i> | en |
| Publisher | Brieflands | en |
| Title | Case Report of <i>Enterobacter cloacae</i> Producing IMP-8 Carbapenemase Isolated from Secretions of Burn Patients and Diabetes Patients with Diabetic Foot | en |
| Type | Case Report | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- jjm-10-12-56006.pdf
- Size:
- 116.46 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF