Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats
| Author | Rahmatollah Parandin | en |
| Author | Shahzad Daroogari | en |
| Orcid | Rahmatollah Parandin [0000-0002-2255-5360] | en |
| Orcid | Shahzad Daroogari [0000-0002-7192-1312] | en |
| Issued Date | 2019-04-30 | en |
| Abstract | Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually used to alleviate pain and Inflammation. The widespread use of NSAIDs has caused the risk and side effects of these drugs commonly increase. Objectives: This study aimed to examine the anti-inflammatory and antinociceptive activities of ethanolic extract of propolis (EEP) in male mice and rats. Methods: In this experimental study, EEP was prepared and administered in doses of 100, 200, and 400 mg/kg of body weight. The anti-inflammatory potential was assessed by inflammatory models of xylene-induced ear edema and cotton pellet granuloma tests, whereas the antinociceptive potential was assessed by formalin and acetic acid-induced writhing methods. Results: The EEP at doses of 100 (P < 0.05), 200 (P < 0.001) and 400 mg/kg (P < 0.001) significantly diminished the foundation of edema caused by xylene. A significant decrease was seen in granuloma weight in EEP at doses of 200 (P < 0.001) and 400 mg/kg (P < 0.001). The extract caused a significant decrease in licking time at first phase in EEP at 100 (P < 0.01), 200 (P < 0.001), and 400 mg/kg (P < 0.001). A significant decrease was observed (P < 0.001) in licking time at the second phase in EEP at doses of 100, 200, and 400 mg/kg. In the writhing model, a significant decrease was observed in the number of writhes in EEP at doses of 100 (P < 0.05), 200 (P < 0.001), and 400 mg/kg (P < 0.001). Conclusions: The findings of this research showed that the ethanolic extract of propolis has considerable anti-inflammatory and antinociceptive activities. | en |
| DOI | https://doi.org/10.5812/zjrms.84150 | en |
| Keyword | Propolis | en |
| Keyword | Anti-Inflammatory | en |
| Keyword | Antinociceptive | en |
| Keyword | Mice | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Anti-Inflammatory and Antinociceptive Activities of the Ethanolic Extract of Propolis in Male Mice and Rats | en |
| Type | Research Article | en |
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