Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran
| Author | Milad Mohammadoo-Khorasani | en |
| Author | Saeedeh Salimi | en |
| Author | Ehsan Tabatabai | en |
| Author | Mahnaz Sandoughi | en |
| Author | Zahra Zakeri | en |
| Orcid | Saeedeh Salimi [0000-0003-3987-0268] | en |
| Issued Date | 2013-10-15 | en |
| Abstract | Background:: Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology. Interleukin-1 receptor antagonist (IL-1Ra) is naturally occurring cytokine that inhibits interleukin-1 (IL-1) activity by binding to the IL-1 receptors without signal transduction. The aim of this study was to investigate the association between IL-1Ra gene 86bp VNTR polymorphism and systemic lupus erythematosus in the South- East of Iran. Materials and Methods:: In this case control study, genetic polymorphism was analyzed in 163 SLE patients and 183 healthy controls. Genotyping of IL-1Ra VNTR polymorphism was determined by gel electrophoresis after PCR amplification. Results:: IL-1Ra VNTR alleles have different copies of 86bp tandem repeats: allele 1 (four repeats), allele 2 (two repeats), allele 3 (five repeats), allele 4 (three repeats) and allele 5 (six repeats). We found an increased frequency of IL-1Ra allele 4 and 1/4 genotype in SLE patients compared to healthy controls (p=0.001 and p=0.002 respectively). Whereas, the frequency of IL-1Ra allele 3 was higher in controls than SLE patients (p=0.01). There was no any association between the IL-1Ra allele 2 and SLE. We did not observe any association between IL-1Ra polymorphism and SLE manifestations. Conclusion:: We concluded that IL-1Ra allele 4 was involved in the pathogenesis of SLE. However, there was no association between the IL-1Ra allele 2 and SLE in South East of Iran. | en |
| DOI | https://doi.org/ | en |
| Keyword | Systemic lupus erythematosus | en |
| Keyword | Interleukin-1 receptor | en |
| Keyword | antagonist | en |
| Keyword | VNTR | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran | en |
| Type | Research Article | en |
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