Methadone Concentrations in Exhaled Breath Condensate, Serum and Urine of Patients Under Maintenance Treatment
| Author | Maryam Khoubnasabjafari | en |
| Author | Khalil Ansarin | en |
| Author | Vahid Jouyban-Gharamaleki | en |
| Author | Vahid Panahi-Azar | en |
| Author | Samin Hamidi | en |
| Author | Zhila Azarmir | en |
| Author | Abolghasem Jouyban | en |
| Issued Date | 2017-10-31 | en |
| Abstract | Drug abuse is a serious problem causing health, economical and psycho-social negative outcomes. Methadone is commonly used drug for management of drug addiction. Exhaled breath condensate (EBC) is a promising non-invasive biological sample which attracted more attention in recent years. This work aimed to extend the applicability of a developed preconcentration – liquid chromatographic method for analysis of methadone in serum and urine samples. Drug concentrations in EBC, serum and urine are also investigated for dose-concentration and their inter-correlations. Biological samples were collected from 53 patients receiving methadone and the concentrations were determined using a validated analytical method after a pre-concentration step. Methadone measured in all samples and there are correlations between administered dose of methadone and its serum and urine concentrations. A weak correlation is observed between dose and EBC concentration. Wider variations in EBC concentrations of methadone could be justified concerning a number of affecting parameters such as relative humidity of the collection area and further investigations are required for standardization of EBC as a non-invasive biological sample to be used in clinical practice. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2127 | en |
| Keyword | Methadone | en |
| Keyword | Exhaled breath condensate | en |
| Keyword | HPLC | en |
| Keyword | Serum | en |
| Keyword | Urine | en |
| Keyword | Correlation | en |
| Publisher | Brieflands | en |
| Title | Methadone Concentrations in Exhaled Breath Condensate, Serum and Urine of Patients Under Maintenance Treatment | en |
| Type | Original Article | en |
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