Erectile Dysfunction and Penile Bulb Dose Following Definitive Prostate Radiation Therapy
| Author | Masoumeh Nouri | en |
| Author | Maryam Kalantari Khandani | en |
| Author | Seyed Alireza Javadinia | en |
| Author | Abdolazim Sedighi Pashaki | en |
| Author | Mohsen Alemi | en |
| Author | Leili Tapak | en |
| Author | Hamidreza Mojtahedi | en |
| Author | Zahra Keshtpour Amlashi | en |
| Orcid | Masoumeh Nouri [0009-0000-2220-6876] | en |
| Orcid | Maryam Kalantari Khandani [0009-0003-1740-1636] | en |
| Orcid | Seyed Alireza Javadinia [0000-0003-2467-837X] | en |
| Orcid | Abdolazim Sedighi Pashaki [0000-0003-2210-5797] | en |
| Orcid | Leili Tapak [0000-0001-9554-3099] | en |
| Orcid | Zahra Keshtpour Amlashi [0000-0001-7126-0393] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Erectile dysfunction (ED) is a common side effect of prostate cancer treatment, affecting up to 50% of patients after radiation therapy. Objectives: This study aims to analyze the correlation between the dose received by the penile bulb (PB) and ED in men who underwent definitive radiation therapy for early-stage prostate cancer without androgen deprivation therapy. Methods: The study included 40 patients who received 3D conformal radiation therapy (3D-CRT) for localized prostate cancer and were reported to be potent before treatment, as determined by the International Index of Erectile Function (IIEF-15) questionnaire. The dose to the PB was measured using dose volume histograms (DVHs), and the IIEF-15 questionnaire was completed again 3 months after 3D-CRT. The Pearson correlation coefficient and linear regression test were used to examine the correlation between the ED score and PB doses. Statistical significance was considered if the P value was less than 0.05. Results: The mean age of the patients was 75.5 ± 5.70 years. The average ED score based on the questionnaire was 15 ± 10.55. Twenty percent of the patients had moderate ED, while 80% had mild ED (all patients reported a decrease in potency after 3D-CRT). However, the correlation between the ED score and the PB mean dose was not statistically significant. Conclusions: This study revealed ED in all prostate cancer patients after 3D-CRT, but no significant correlation was found between the dose received by the PB and radiotherapy-induced impotence. | en |
| DOI | https://doi.org/10.5812/ijcm-147952 | en |
| URI | https://brieflands.com/journals/ijcm/articles/147952 | en |
| Keyword | Radiation Therapy | en |
| Keyword | Prostate Cancer | en |
| Keyword | Prostate Cancer; Penile Bulb | en |
| Publisher | Brieflands | en |
| Title | Erectile Dysfunction and Penile Bulb Dose Following Definitive Prostate Radiation Therapy | en |
| Type | Research Article | en |
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