Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
| Author | Farzin Hadizadeh | en |
| Author | Hossein Hosseinzadeh | en |
| Author | Vahideh-Sadat Motamed-Shariaty | en |
| Author | Mahmood Seifi | en |
| Author | Shahab Kazemi | en |
| Issued Date | 2008-01-31 | en |
| Abstract | Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.741 | en |
| Keyword | Forced swimming model | en |
| Keyword | Antidepressant | en |
| Keyword | MAOIs | en |
| Keyword | Imidazolecarboxamides | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model | en |
| Type | Research Article | en |
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