Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin
| Author | Zahra Hami | en |
| Issued Date | 2020-04-21 | en |
| Abstract | Background: Curcumin is an active non-toxic component of turmeric and is a substance with strong anti-inflammatory and antioxidant properties. Iron, as a micronutrient, plays an important role in physiological processes. Chitosan is a natural polymer derived from chitin and is known as a biocompatible product due to its high biocompatibility, non-toxicity, and biodegradation to harmless products. Objectives: This study aimed to design and synthesize a modified magnetic nanoparticle to be used as a targeted drug delivery system. Methods: Nanocurcumin loading was performed on the surface of chitosan-modified iron magnetic nanoparticles in two stages. In the first stage, chitosan was loaded on the surface of iron magnetic nanoparticles as a coating polymer. In the next step, the final reaction took place by the loading of nanocurcumin on the surface of magnetic iron nanoparticles modified by chitosan. Results: The results of transmission electron microscopy and scanning electron microscopy demonstrated the structure, morphology, physicochemical properties, and presence of nanocurcumin layers on chitosan in nanoparticles with a diameter of 20 nm. In the Fourier transform infrared spectroscopy, the iron-oxygen peak indicated the magnetic nanoparticles of iron, and the oxygen-hydrogen peak showed nanocurcumin layers on chitosan. Moreover, X-ray spectroscopy confirmed the presence of these elements in the final composition by showing iron, carbon, oxygen, and nitrogen peaks. Conclusions: The results of this study showed that nanocurcumin was successfully loaded on the surface of magnetic iron nanoparticles modified by chitosan. | en |
| DOI | https://doi.org/10.5812/amh.103657 | en |
| Keyword | Chitosan | en |
| Keyword | Curcumin | en |
| Keyword | Iron | en |
| Keyword | Nanoparticles | en |
| Keyword | Spectrophotometry | en |
| Publisher | Brieflands | en |
| Title | Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin | en |
| Type | Research Article | en |