Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India
| Author | Sushmita Pathy | en |
| Author | Soumyajit Roy | en |
| Author | Prabhat Singh Malik | en |
| Author | Bidhu Kalyan Mohanti | en |
| Author | Vinod Raina | en |
| Issued Date | 2016-12-31 | en |
| Abstract | Objectives: To evaluate treatment compliance, toxicity and survival in geriatric patients (≥65 years) with locally advanced non-small cell lung cancer (LA-NSCLC). Methods: Departmental archive was collected for the details of demographics, treatment and outcome in elderly patients with LA-NSCLC (2008 - 2013) (n = 96). Both progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Acute and late morbidity were scored using common terminology criteria for adverse events version 4, radiation therapy and oncology group late morbidity scoring system. Results: Overall treatment completion rate was 65%. The rates of acute grade ≥ 3 hematologic and non-hematologic toxicities were 20% and 17% respectively. Overall rate of late toxicity was 12.5%. The median PFS and OS values were 7.4 months and 10.54 months, respectively. Patients with multiple comorbidities, poor socio-economic background and serum albumin level (< 3.5g/dL) were observed to have poor survival. Survival was lower for non-compliant patients. Conclusions: Curative multi-modality therapy in elderly patients with LA-NSCLC is a challenging task. They are susceptible to poor compliance, treatment-associated toxicities and poor survival. | en |
| DOI | https://doi.org/10.17795/ijcp-5481 | en |
| Keyword | Geriatric Patients | en |
| Keyword | Locally Advanced NSCLC | en |
| Keyword | Toxicity | en |
| Keyword | Compliance | en |
| Keyword | Survival | en |
| Publisher | Brieflands | en |
| Title | Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India | en |
| Type | Research Article | en |
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