Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells
| Author | Hasti Sarabikia | en |
| Author | Razieh Souri | en |
| Author | Mohsen Safaei | en |
| Orcid | Mohsen Safaei [0000-0003-3885-6640] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions. | en |
| DOI | https://doi.org/10.5812/jkums-140157 | en |
| URI | https://brieflands.com/journals/jkums/articles/140157 | en |
| Keyword | Cancer | en |
| Keyword | Oral Squamous Cell Carcinoma | en |
| Keyword | Magnesium Oxide Nanoparticles | en |
| Keyword | Polyvinyl Alcohol | en |
| Publisher | Brieflands | en |
| Title | Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells | en |
| Type | Research Article | en |