Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice

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AuthorMina Shojaedinien
AuthorMasoud Hemadien
AuthorGhasem Sakien
AuthorFereshtesadat Fakhredinien
AuthorMohammad Javad Khodayaren
AuthorLayasadat Khorsandien
OrcidMina Shojaedini [0009-0008-4257-5546]en
OrcidMasoud Hemadi [0000-0002-3738-703X]en
OrcidGhasem Saki [0000-0001-5268-8407]en
OrcidFereshtesadat Fakhredini [0000-0002-7766-3369]en
OrcidMohammad Javad Khodayar [0000-0001-9518-1286]en
OrcidLayasadat Khorsandi [0000-0002-3391-3055]en
Issued Date2024-09-30en
AbstractBackground: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P < 0.01), and reduced LC3-II levels (P < 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice.en
DOIhttps://doi.org/10.5812/jjcmb-151663en
URIhttps://brieflands.com/journals/jjcmb/articles/151663en
KeywordThymoquinoneen
KeywordCisplatinen
KeywordAutophagyen
KeywordTestisen
PublisherBrieflandsen
TitleThymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Miceen
TypeResearch Articleen

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