Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice
| Author | Mina Shojaedini |
| Author | Masoud Hemadi |
| Author | Ghasem Saki |
| Author | Fereshtesadat Fakhredini |
| Author | Mohammad Javad Khodayar |
| Author | Layasadat Khorsandi |
| Accessioned Date | 2024-09-25T01:32:13Z |
| Available Date | 2024-09-25T01:32:13Z |
| Issued Date | 2024-09-30 |
| Abstract | Background: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P < 0.01), and reduced LC3-II levels (P < 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice. |
| DOI | https://doi.org/10.5812/jjcmb-151663 |
| URI | https://repository.brieflands.com/handle/123456789/63797 |
| Keyword | Thymoquinone |
| Keyword | Cisplatin |
| Keyword | Autophagy |
| Keyword | Testis |
| Publisher | Brieflands |
| Title | Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice |
| Type | Research Article |
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