Jentashapir Journal of Cellular and Molecular Biology

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In Collaboration with Ahvaz Jundishapur University of Medical Sciences

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Jentashapir Journal of Cellular and Molecular Biology, JJCMB, publishes original research papers, reviews, meta-analyses, short communications, mini-reviews, commentaries, letter to editors, and case reports in the fields of cellular and molecular biology which demonstrate new advancements and novel results. Additionally, JJCMB publishes all studies in basic, clinical and translational studies. This journal also welcomes studies which focus on new cellular and molecular techniques which promote prognosis, diagnosis, and early diagnosis of human diseases and disorders.

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Now showing 1 - 20 of 495

Aerobic Exercise Improved Diacylglycerol/Protein Kinase C and Phosphatidylinositol 4,5-Biphosphate Pathway in Cardiac Tissue of Obese Rats
(Brieflands, 2024-09-30) Masoomeh Jamalpour Dezki; Marina Shariati
Background: Obesity, characterized by abnormal accumulation or excess lipids, is a major cause of increased incidence of cardiovascular diseases. Objectives: The purpose of this experiment is to investigate the effect of aerobic exercise on the expression of sn-1,2-diacylglycerol (DAG), Protein kinase C (PKC), and Phosphatidylinositol 4,5-biphosphate (PIP2) genes in experimental rat models of diet-induced obesity. Methods: Twenty-four Wistar rats were randomly divided into four groups: (1) control, (2) obesity, (3) exercise, and (4) obesity + exercise. At the end of the experiment, cardiac hypertrophy markers and real-time PCR were used to evaluate and compare the gene expression levels of DAG, PKC, and PIP2 in cardiac tissue across all groups. Results: A high-fat diet containing fructose significantly increased the gene expression levels of DAG, PKC, and PIP2 in the cardiac tissue of obese rats compared to the control group. However, 6 weeks of aerobic exercise led to a significant decrease in DAG and PKC gene expression compared to the obese rats. Although there was no significant change in PIP2 gene expression in the obesity + exercise group compared to obese rats. Conclusions: Based on the results of this study, it appears that aerobic exercise can modulate the expression of DAG and PKC genes, which play a critical role in cardiac remodeling.
Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice
(Brieflands, 2024-09-30) Mina Shojaedini; Masoud Hemadi; Ghasem Saki; Fereshtesadat Fakhredini; Mohammad Javad Khodayar; Layasadat Khorsandi
Background: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P < 0.01), and reduced LC3-II levels (P < 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice.
The Effect of Increasing Aerobic Exercise on the Expression of NF-κB and COX-2 Genes in Heart Tissue of Rats Under a High-fat Diet
(Brieflands, 2024-09-30) Flora Farahbakhsh; Rahmatulah Khanmohamadi
Background: Several studies have shown that obesity alters the function and structure of the heart. Objectives: This study examined the impact of increasing aerobic exercise (IAE) on the mRNA expression of Cyclooxygenase-2 (COX-2) and nuclear factor Kappa B (NF-κB) in the cardiac tissue of rats fed a high-fat diet (HFD). Methods: Twenty-four male Wistar rats were divided into two groups and fed two types of diets for eight weeks: Control and HFD groups. After eight weeks, the rats on the HFD were further divided into HFD and HFD + IAE groups. The exercise program was conducted for six weeks, with five sessions per week, progressing from moderate to high intensity. The program followed the principle of gradual overload and was based on the maximum speed of the rats. The expression of COX-2 and NF-κB genes was assessed. Results: The expression of COX-2 and NF-κB genes increased in the HFD group compared to the control group. After six weeks, the expression of NF-κB and COX-2 genes decreased in the HFD + IAE group compared to the HFD group. Conclusions: Six weeks of IAE appears to reduce the inflammatory process in rats with HFD-induced obesity.
The results of Pars Plana Vitrectomy in patients with Intraocular Foreign Body
(Brieflands, 2012-06-30)
Background: To identify the clinical features in eyes with intraocular foreign bodies (IOFBs) and evaluate the results of surgical management in these cases. Material and methods: In a descriptive retrospective study, the records of 32 eyes of 32 patients with IOFBs were reviewed. All eyes underwent pars plana vitrectomy between April 2001 and February 2012. The IOFBs were removed either with intraocular forceps or magnetic extraction. Results: All patients were men with the mean age of 30.26 years. The average follows up period was 25.16 months. The IOFBS was ferromagnetic in 25 (70.5%). The IOFBs were extracted with external magnet in 17 eyes (50%) and with intraocular forceps in 12 eyes (35.2%). Macular pucker and scar were present in six eyes (18.7%). Final visual acuity was 20/40 or better in 7 eyes (21.9%) and 20/200 or better in 16 eyes (50%). There were no significant relationship between the final visual acuity of 20/200 or better and the site (P=0.59), size (P=0.53), type of IOFBs (P=0.39), and time interval between trauma and surgery (P=0.34).
Green Copper Carbonate Nanoparticles Produced by the Ureolytic Fungus Alternaria Species Strain ccf7 and Their Antibacterial Activity
(Brieflands, 2023-06-30) Morahem Ashengroph; Zahra Rabiei
Background: Copper carbonate nanoparticles have several applications in the fields of pigments, insecticides, and fungicides. They are also used as catalysts in chemical processes and crude oil desulfurization. Fungi can biosynthesize metal nanoparticles due to their high tolerance, extracellular synthesis, simplicity of extraction, and large-scale exploitation. Objectives: This study aimed to investigate the potential of fungal isolates (which are resistant to copper chloride with urease activity) as biocatalysts for the synthesis of copper carbonate nanoparticles. This approach was considered due to the advantages of using fungal isolates in nanoparticle biosynthesis. Methods: In a PDA culture medium with 25 mM copper chloride, an enrichment culture was used to isolate copper-resistant fungal isolates. Fungal isolates’ urease enzyme was qualitatively assessed using 2% urea agar-based culture media. Studies on the synthesis of copper carbonate nanoparticles and the effect of different parameters on the synthesis of these nanoparticles were conducted using a mycelium-free supernatant strategy. Field emission scanning electron microscope (FESEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy (FTIR) studies were used to determine the properties of calcium carbonate nanoparticles. The selected fungal isolate was identified using macroscopic and microscopic characteristics, as well as molecular analysis using amplification of the ITS1-5.8S-ITS2 gene sequences. Results: Alternaria species strain ccf7 (GenBank accession number OP242500) was chosen as the superior strain for copper carbonate nanoparticle synthesis tests based on the pattern of resistance to copper chloride salt and the qualitative assessment of urease activity. Based on the findings of the electron microscope studies, spherical copper carbonate nanoparticles with an average size of 66.7 nm were synthesized after 24 hours of incubation at the optimal concentration of 45mM copper chloride, temperature of 25°C, and shaker speed of 100 rpm. The distribution of the produced nanoparticles was appropriate, as indicated by a polydispersity index (PDI) of 0.25. The strongest inhibitory impact of these copper carbonate nanoparticles was against Pseudomonas aeruginosa, with an average inhibition of 31 mm at a concentration of 50 mg/L, according to the results of their antibacterial activities. Conclusions: For the first time, the synthesis and development of a green approach for the fabrication of copper carbonate nanoparticles using the genus Alternaria have been proposed in this study.
Prevalence of Colorectal Cancers in Isfahan Province, Iran
(Brieflands, 2019-04-30) Zahra Tolou-Ghamari
Background: Colorectal cancer (CRC) as the most frequent malignant disease of the gastrointestinal tract, shows around 9.5% of all incident cancer internationally. However, different countries report dissimilar rates in incidence, but the rates change with time. Objectives: The aim of this study was to provide information associated with the CRC rate of incidence in Isfahan Province, Iran. Methods: This investigation was accompanied by Isfahan Kidney Transplantation Research Center. Data were collected from the Isfahan Cancer Registry. Period prevalence (PP) and incidence rate (Irs) were considered and reported per 100,000 persons. Results: In all, there were 2623 patients with CRC comprised of 2112 alive and 511 deceased reported individuals. For the total population, the PP was calculated as 52.6 and Irs significantly increased (P < 0.01) from 10.3 to 15.1 per 100,000 people. The mean (SD, range) age of the patients was 62.0 (14.4, 3 - 98) years. The total PP was corresponded to a value of 22.6 for females and 30.1 for males. Conclusions: There was a 47% increase in the rate of incidence over the investigated period. The PP was 6.8% higher in males than in females. In relation to the age, cancers occurred in 82% after 50 years old of life. Therefore, for allocation of health-care resources and attention toward strategic-based decisions, further studies in this direction seem to be advantageous.
The Content and Convergent Validity of the Persian Morningness-Eveningness Personality Questionnaire in Employees: A Personality Profile Distribution
(Brieflands, 2019-07-21) Gholamreza Rajabi
Background: The people with morningness orientation wake up early morning, and people with eveningness orientation wake up with difficulty. Objectives: The purpose of this study was to investigate the content and convergent validity of the Persian Morningness-Eveningness Personality Questionnaire in employees and a personality profile distribution. Methods: The current study is a descriptive type of survey, which 200 employees of Shahid Chamran University Ahvaz were randomly selected among the population of Shahid Chamran University employees. They completed the Morningness-Eveningness Personality Questionnaire, and Late/Early Sleep Preferences Scale. Results: The content validity ratio indicated that the total of experts agreed on that there was an association between the items and domain of 0.54 to +1. The Cronbach’s alpha coefficient was 0.82 for the entire questionnaire. The coefficients of each item with the total score of MEPQ ranged from 0.25 to 0.57. The convergent validity coefficient for this questionnaire with Late/Early Sleep Preferences Scale was significant (P < 0.001). The personality profile revealed that about 143 (71.5%) of the 200 participants fell into the intermediate category. Conclusions: Given the validity and reliability of the Morningness-Eveningness Personality Questionnaire, this questionnaire can be used in professional, industrial, and occupational environments to assign people to specialized and non-specialized jobs.
Evaluation of Low Intensity Pulsed Ultrasound Effects on the Osteogenesis Potential of Demineralized Bone Matrix in Experimental Tibial Defect in Rabbits
(Brieflands, 2016-10-01) Maryam Ezzati Givi; Ali Baniadam; Saleh Esmaeilzadeh; Alireza Ghadiri; Shahin Gohar Pey
Background: Many studies have assessed the effects of either low intensity pulsed ultrasound (LIPUS) or demineralized bone matrix (DBM) on bone repair; however, an evaluation of the combination of these modalities (LIPUS + DBM) has not yet been considered. Objectives: This study aimed to investigate combined effects of DBM and LIPUS on fracture healing. Methods: Bilateral 5-mm tibial defects were created in male Dutch rabbits (n = 30). Animals were divided to two groups of empty defect (A) and DBM group (B), in which commercial DBM putty was used in defects. In each animal left tibia was treated with LIPUS (intensity = 30 mW/cm2, I SATA, 1 MHz, 20 min/day, pulsed duty 1:4) and the contralateral limb was used as the control. Animals, after 14, 28 and 60 days, were submitted to radiographic or computerized tomography (CT) scanning analysis. Results: At two weeks, LIPUS had no substantial effect on bone formation. Slight increase of average rates in LIPUS group (A2) were seen compared to the empty defect group (A1) at day 21 and 28. In the DBM–treated group compared with the sham LIPUS, bone-healing rate was reduced at the end of the period (60 days) after surgery. The average healing rate in group B at the end of the 60-day period was less than group A after 21 days. Conclusions: The present study discusses systemic effect of LIPUS because of non-significant results between treated group and control group and is the first to demonstrate that LIPUS decreases bone formation induced by DBM.
Comparison of Personality Traits Between Psychopathic Prisoners, Non-Psychopathic Prisoners, and Non-Prisoner Patients
(Brieflands, 2019-07-21) Davod Ghaderi; Lili Amirsardari; Mansoor Agashteh
Background: Research in the field of personality has tried to recognize the main traits that reflect the building blocks of personality. For instance, personality dimensions, especially the five-factor model, deals with the field of personality disorder, especially the psychopathic personality disorder. Objectives: The purpose of this study was to analyze and compare the personality traits of psychopathic prisoners, non-psychopathic prisoners, and non-prisoner patients separated by gender in Tehran. Methods: This descriptive-comparative study was conducted on 355 participants including 202 male prisoners, 105 female prisoners, and 48 non-prisoner patients. All the participants filled out the Hare Psychopathy Checklist and the Revised Neuroticism-Extraversion-Openness Five-Factor Inventory. The data were analyzed by the Pearson correlation coefficient, regression analysis, one-way analysis of variance (one-way ANOVA), and Scheffe’s post hoc test. Results: The results showed that there was a significant positive correlation between psychopathy and extraversion and a significant negative relationship between psychopathy and openness, agreeableness, and conscientiousness in male prisoners. The relationships were significant at the level of 0.1. Conclusions: By comparing male psychopathic and non-psychopathic prisoners, female psychopathic and non-psychopathic prisoners, and non-prisoner non-psychopathic patients, it was found that psychopathic prisoners had lower levels of agreeableness, conscientiousness, and openness than the other groups.
Survey of Complications of Peripheral Venous Catheterization at an Intensive Care Unit of (ICU) of Susa City
(Brieflands, 2016-10-01) Maryam Hedayatinejad; Sadighe Fayazi; Simin Jahani; Amal Sakimalehi; Ehsan Hedayatinejad
Background: Peripheral catheters are the most common invasive procedures in patients, and have several therapeutic uses, yet result in infectious and non-infectious complications as well as problems such as pain and bruising, drug and fluid leakage out of the vessels, ecchymosis, hematoma, thrombosis, embolism, infection and phlebitis. Objectives: The aim of this study was to evaluate the complications of peripheral veins catheterization and some related factors at an intensive care unit (ICU) of Susa city. Methods: This descriptive cross sectional study was conducted on 224 catheters in patients, who were hospitalized for at least 48 hours at the intensive care unit. Data was collected through a questionnaire (demographic information, medications, catheter number, catheter site and placement) and a checklist of catheter mechanical complications and phlebitis checklist. Review of the catheter site was done as well (at first, second, third and fourth, twelfth hour). To analyze the data, descriptive and analytical statistics (chi-square and Mann-Whitney) were used, and the significance level was considered as P < 0.05. Results: The highest frequency was found in the age group of 30 to 60 years old. Results showed no significant correlation between age and incidence of complications and phlebitis, the insertion of catheter, and catheter assembly site (P > 0.05). A significant correlation was reported between variables such as type of drugs, catheter survival time, and work shift (P < 0.05). Conclusions: Due to mechanical problems and phlebitis caused by peripheral catheters, choosing the right location and proper care and management of catheters can reduce the risk of complications and prevent overload to the patient and system due to increased skills by using educational programs.
Isodose 2D determining in water phantom regular and irregular fileds in radiation therapy for caculation modulated dose
(Brieflands, 2013-06-30) Mohamad Javad Tahmasebi Biragani; Nahid Chegeni; Mansur Zabihzade; Shole Arvandi; Sasan Razmjoo Ghalaee; Fatemeh Seif
Background: The dose distribution plays an importance role in the commercial treatment planning algorithm; therefore, a patient-independent model is needed to calculate the modulated profile.
The Level of sport competitive anxiety in elite basketball players and its relationship with sport injuries
(Brieflands, 2012-06-30)
Background: The effect of psychological factors in the context of a growing number of sports, prevention of sports injuries, exercise rehabilitation and as an effective tool for managing stress and anxiety in the race has been confirmed by various studies ?The purpose of the present study was to determine the level of sport competitive anxiety in Iranian elite Basketball player and its relationship with sport injuries. Material and methods: The study sample included 144 of the basketball players participating in the Iranian Basketball Super league competition that 127 of them were tested. A demographic questionnaire, SCAT questionnaire and injury questionnaire were used to gather the data. Independent T test, ANOVA test and Pearson correlation coefficient were used for data analysis. Results: The results showed 83.1 percent of elite basketball players have injured the lower competitive anxiety, while 15.6 percent of competitive anxiety, moderate and only 1.3 percent had had a high competitive anxiety. In non injured basketball players, 82 percent had a low level of anxiety while 14 percent had a moderate level and 4% had a high level of anxiety.
Factors Related to Delay in Seeking Medical Care Among Patients with Acute Myocardial Infarction in Dhaka
(Brieflands, 2019-07-15) Fahima Khanam; Md Shariful Islam; Jotsna Akter; Won Hee Lee
Background: Acute myocardial infarction (AMI) has been considered the leading cause of death and disability all over the globe where Bangladesh is not an exception. Early medical attention seeking behavior is decisive for saving valuable lives and reducing further complications. Objectives: Current research aimed to identify the factors related to delay in seeking medical care among AMI sufferers. Methods: This descriptive cross-sectional study was carried out by face-to-face interview from January 2017 to June 2018. A total of 120 patients were conveniently recruited from Ibrahim Cardiac Hospital and Research Institute, which is a tertiary level hospital in Dhaka. Delay in medical care seeking time was investigated using a pretested semi-structured questionnaire. Data were evaluated by Statistical Package for the Social Science version 20 and the relationship was assessed by using t-test. Results: Respondents who lived in the rural area (P = 0.01), whose pain duration less than 6 hours (P = 0.01) and radiation of pain (P = 0.02), took self-treatment (P = 0.04), misinterpretation of symptoms (P = 0.04), living long distance (P = 0.01), lack of suitable transport (P = 0.04), and faced traffic jam (P = 0.00) showed significantly higher delay in seeking medical care. Conclusions: It is necessary to develop a strategy for reducing delay in medical care seeking in patients with AMI to reduce cardiovascular mortality and morbidity. Proper education regarding major cardiovascular events could be an effective option.
Molecular Analysis of rs2910164 Polymorphism and its Association with TNF-α Gene Expression in Colorectal Cancer
(Brieflands, 2021-06-30) Ahmad Hamta; Niloofar Tolooi
Background: Colorectal cancer (CRC) is one of the most common malignant tumors in the world, which has been introduced as the third most common cancer and the third leading cause of death. This cancer is uncommon before the age of 50. Its prognosis is controversial, and many studies report a poor prognosis in older patients, and the others show no difference. In addition to the factors, such as diet, environmental factors, somatic, and hereditary mutations, genetic factors, including altered expression of some microRNAs and mutations in tumor necrosis factor-α (TNF-α) gene, may be involved in CRC. Objectives: This study aimed to investigate the rs2910164 polymorphism from the miRNA146a gene and its association with the expression of TNF-α gene in CRC before and after the age of 50 for early diagnosis and treatment. Methods: In this study, 65 formalin-fixed paraffin-embedded (FFPE) tissue samples from patients with cancerous lesions of colorectal tissue (37 cases over 50 years were considered as the case group and 28 cases under 50 years were considered as the control group). DNA was extracted from the samples, and rs2910164 polymorphism of the miRNA146a gene was investigated by PCR. Moreover, RNA was extracted from the samples, and the expression of the miRNA146a and TNF-α genes were evaluated. Finally, Epi Info software version 7.1.3.10 and MedCalc Version 19.2.0 were used for data analysis. Results: The frequency of GG, GC, and CC genotypes from rs2910164 polymorphism of miRNA146a gene in the control group was 0.29, 0.46, and 0.25, respectively, but in the case group, it was 0.54, 0.38, and 0.08, respectively. The results also showed that the expression of miRNA146a (P = 0.00006) and TNF-α (P = 0.009) genes was higher in the case group than in the control group. Conclusions: Based on the results of this study, a significant correlation was found between GG genotype and rs2910164 polymorphism of miRNA146a gene and TNF-α gene expression in the CRC samples. Therefore, investigation of these factors may be helpful in patients with CRC over 50 years.
Evaluation of Ginkgo biloba and Flunixin in BIM Gene Expression and Viability of Ovarian Cancer Cell A2780s
(Brieflands, 2021-09-30) Farnoosh Soleamani; Elham Salehi; Majid Morovati-Sharifabad; Fatemeh Sarkargar; Gholamhosein Pourghanbari
Background: Ovarian cancer is the deadliest gynecologic cancer. Studies on the therapeutic properties of Ginkgo biloba and flunixin showed that these drugs, singly or in combination with other drugs, have anti-cancer activities. Different genes are involved in apoptosis regulation. The BIM gene is one of the most important regulators of this process. BIM has different roles, including cell cycle regulation, apoptosis induction, deoxyribonucleic acid recombination, chromosomal segregation, and cell aging. Methods: This study evaluated the viability percentage of the A2780s cell line with Ginkgo biloba and flunixin at different concentrations, compared to that of the control group. Then, the half-maximal inhibitory concentration (IC50) values of Ginkgo biloba and flunixin were determined within 24 h. Then, the expression of the BIM gene was evaluated using a real-time polymerase chain reaction (PCR). Results: The IC50 results showed that Ginkgo biloba and flunixin significantly reduced cell life (P < 0.01) depending on time and concentration. The results of real-time PCR showed that cell treatment with Ginkgo biloba and flunixin significantly increased BIM expression. Conclusions: The results of this experiment indicated that BIM gene expression was increased in cancer cells treated with Ginkgo biloba and flunixin, compared to that reported for control cells. Therefore, with further research in the future, these compounds can be used for the development of ovarian anti-cancer drugs.
Factors Influencing the Cerebroplacental Ratio in Non-Severe Small for Gestational Age Fetuses at the Age of 28 - 38 Weeks of Gestation
(Brieflands, 2019-07-20) Mojgan Barati; Razeih Mohammad Jafarei; Sareh Aberoumand; Kobra Shojaei; Yalda Jefride; Sara Masihi; Mahintaj Najafian
Background: Cerebroplacental ratio (CPR) is an important indicator for predicting adverse outcomes during pregnancy. It is derived from the division of the PI Doppler index from the middle cerebral artery (MCA) into the umbilical cord vessels. Objectives: To characterize the relationship between CPR and some factors such as diabetes, gestational hypertension, body mass index (BMI), PAPP-A, and drug use. Methods: This descriptive-analytic study was conducted in Ahvaz in 2016. In this study, the CPR was evaluated in 230 pregnant women who were at 28 - 38 weeks of gestational age, except for pregnant women with severe Small for gestational age (SGA) and multiple pregnancies. In this study, a number of factors such as diabetes mellitus, gestational hypertension, BMI, PAPP-A, and drug use were investigated. Data were analyzed using SPSS software, version 19. Results: In this study, there is a relationship between CPR and diabetes mellitus, gestational hypertension, and maternal drug use. There is not a relationship between CPR and BMI and PAPP-A. Conclusions: Diabetes and gestational hypertension are two factors that influence the cerebroplacental ratio.
The Effect of Aerobic Training and Cholecalciferol on IGF-I and IGFBP-3 in the Bone Tissue of Rats Poisoned with Hydrogen Peroxide
(Brieflands, 2022-09-30) Ramin Eimari Eskandari; Hasan Matinhomaee; Lida Moradi
Background: Exercise and vitamin D can improve bone density by reducing bone loss. Growth factors such as IGF-I and IGFBP-3 are appeared to increase bone turnover in response to mechanical load, and free radicals attenuate the release of these growth factors. Objectives: We assessed the effect of concurrent aerobic training and cholecalciferol administration along with hydrogen peroxide injection on the levels of IGF-I and IGFBP-3 expression in the bone tissue of rats. Methods: Thirty-six adult Wistar rats were randomized into six groups (n = 6), including healthy control, sham, hydrogen peroxide (H2O2), H2O2 + aerobic training, H2O2 + cholecalciferol, and H2O2 + aerobic training + cholecalciferol. The rats were intraperitoneally administered with one mmol/kg. Body weight (BW) of H2O2 three times a week on even days and 0.5 μg/kg.bw of cholecalciferol daily. Aerobic training (at a speed of 4 - 20 m/min, for 20 - 60 minutes) was performed five days/w for eight weeks. The expression of IGF-I and IGFBP-3 was measured by real-time (RT)-PCR. Data were analyzed using the independent t-test, two-way ANOVA (exercise × vitamin D), and Bonferroni’s post-hoc test in SPSS 26 at the significance level of P ≤ 0.05. Results: The results showed that H2O2 significantly reduced the gene expressions of IGF-I (P = 0.001) and IGFBP-3 (P = 0.001) in the bone tissue. Also, exercise and vitamin D augmented the expression of IGF-I (P = 0.008) and IGFBP-3 (P = 0.0001) as post-hoc analysis showed that aerobic training had the greatest effect on the expression of IGF-I and IGFBP-3 (P < 0.05). In addition, the amplifying effects of aerobic training and cholecalciferol on the gene expressions of IGF-I and IGFBP-3 were also remarkable (P < 0.1). Conclusions: The mechanical load created by aerobic training exerted the greatest augmenting effect on the gene expression of IGF-I and IGFBP-3. Moreover, the interactive effect of aerobic training and cholecalciferol was also significant.
Effect of smoking Tobacco in the etiology of cancer of larynx in Khuzestan
(Brieflands, 2011-06-30)
Background: Laryngeal cancer though accounts for only 1.5% of all malignant neoplasm. Scientific evidence has shown that cancers of the oral cavity, larynx, lung and esophagus are associated with Cigar smoking. The present study is to examine by case-control method the impact of smoking on laryngeal cancer. Material and methods: One hundred and six hospitalized cases of otolaryngology department of Imam and Apadana Hospital of Ahvaz Jundishapur university diagnosed and pathologically confirmed laryngeal cancer in the period between March 1990 and March 2007 were selected for study. At the same time 176 controls of the otolaryngology department hospitalized in the same period for non-tumor diseases of the head and neck were selected. The questionnaire used in the present study contained items such as the social and demographic background of the subject, history of otolaryngology diseases, and lifestyle of the patients before hospitalization, smoking habit, and amount and duration of smoking. All data was analyzed by SPSS16. Results: cases and controls were not significantly different in sex, marital status, race, educational level, religious belief and area of residency (P>0.05). Age ,smoking experience ,total year of smoking ,way of smoking and the total amount of smoking were statistically associated with laryngeal cancer (P
The survey of neoplasm classification systems In educational hospitals of Iran,Tehran,Shahid Beheshti & Jondi Shapor universities
(Brieflands, 2011-06-30)
Background: The collection of information concerning neoplasm is of major interest, but medical data are only meaningful once they are classified according to a valid and reliable classification. : So the purpose of this study was to survey current neoplasm classification systems. Material and methods: This research study is descriptive and useable. Informations collected by library studies and by question arises. Results: Research result show that most of medical record yards in study group use of ICD10 book to neoplasm classification also 44precent of statistical society use of commandments and rules of dead causes classification in second part of ICD10 book. 100 percent of statistical society didnt have any training about ICD-O. Conclusion: according to research result we can conclude that clinical data extracted from correct sources. But because staff of medical recorders lack of knowledge and they dont use of ICD-O, tumor registry statistics is so different from WHO standards.
The Study of clinical decision support systems role in health Care (1980-2010)
(Brieflands, 2011-11-30) Zohreh Omidian; Ali Mohammad Hadianfard
Background: Clinical decision support systems (CDSS or CDS) are interactive computer programs, which are designed to assist physicians and other health professionals with decision making tasks.

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