Formulation and <i>In-vitro</i> Evaluation of Orally Disintegrating Tablets of Olanzapine-2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex
| Author | Kulkarni Ajit Shankarrao | en |
| Author | Ghadge Dhairysheel Mahadeo | en |
| Author | Kokate Pankaj Balavantrao | en |
| Issued Date | 2010-10-31 | en |
| Abstract | The aim of this study was to design orally disintegrating tablets of Olanzapine and to complex Olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. Phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. Tablets were prepared by using superdisintegrants namely, sodium starch glycolate, croscarmellose sodium, crospovidone, tulsion 339, and indion 414. Complex was characterized using infrared spectroscopy, drug content estimation, saturated solubility study, diffrerential scanning calorimetry and X-ray diffractometry. 5% w/w croscarmellose sodium showed the minimum disintegration time 39 ± 1.76 sec and in-vitro drug release 99.19 ± 0.18% within 6 min. In general, solubility of Olanzapine can be improved by complexing with 2-hydroxypropyl-β- cyclodextrin. Croscarmellose sodium can be used for faster disintegration of tablets. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.899 | en |
| Keyword | Orally disintegrating tablets | en |
| Keyword | Olanzapine | en |
| Keyword | Olanzapine-2-hydroxypropyl-β- cyclodextrin inclusion complex | en |
| Keyword | Phase solubility analysis | en |
| Publisher | Brieflands | en |
| Title | Formulation and <i>In-vitro</i> Evaluation of Orally Disintegrating Tablets of Olanzapine-2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex | en |
| Type | Original Article | en |
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