The Incidence of Amikacin Ototoxicity in Multidrug-ResistantTuberculosis Patients
| Author | Mohammad Reza Javadi | en |
| Author | Bahareh Abtahi | en |
| Author | Kheirollah Gholami | en |
| Author | Behzad Safari Moghadam | en |
| Author | Payam Tabarsi | en |
| Author | Jamshid Salamzadeh | en |
| Issued Date | 2011-10-31 | en |
| Abstract | Amikacin has been shown to irreversibly suppressCochlear activity.The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB) were included.All patients received fixed dose of intravenous amikacin(500 mg/day) and anti-TB medications for six months. Baseline Pure-Tone Audiometry (PTA) was performed on all patients,before and during the drug treatment with the frequency range between 250 Hz and 8000 Hz. Patients were closely observed for the occurrence of symptomatic ototoxicity using a questionnaire .To find an association between the incidence of cochlear damage and patients’ demographics, all patients’ data were recorded. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.979 | en |
| Keyword | Ototoxicity | en |
| Keyword | Amikacin | en |
| Keyword | Multidrug-resistant tuberculosis | en |
| Keyword | Pure-tone audiometry | en |
| Publisher | Brieflands | en |
| Title | The Incidence of Amikacin Ototoxicity in Multidrug-ResistantTuberculosis Patients | en |
| Type | Original Article | en |
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