Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents

Simple item page
AuthorMaryam Baharlouien
AuthorSayed Ahmmad Mirshokraeeen
AuthorAzam Monfareden
AuthorMohammad Hassan Houshdar Tehranien
Issued Date2019-07-31en
AbstractCancer disease is a great concern in the worldwide public health and current treatments do not give satisfactory results, so, developing novel therapeutic agents to combat cancer is highly demanded. Nowadays, anticancer peptides (ACPs) are becoming promising anticancer drug candidates. This is due to several advantages inherited in peptide molecules, such as being usually with small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence, and more modification sites for functionalization. To get benefit of these merits, in this work, we synthesized a new series of triazole- based analogues with peptide scaffold by employing click chemistry and evaluated their anticancer activities against breast, colon cancer cell lines as well as fibroblast cells using MTT assay. Our results suggest that peptide scaffolds containing 1H-1, 2, 3-triazole ring group are toxic against colon and breast cancer cells viability, and this effect was more pronounced on MDA-MB-231 cells compared with MCF-7 breast cells. As a conclusion, these designed peptide analogues may be good and safe candidates as future anticancer agents.en
DOIhttps://doi.org/10.22037/ijpr.2019.111722.13320en
URIhttps://brieflands.com/journals/ijpr/articles/126183en
KeywordClick chemistryen
KeywordTriazole ringsen
KeywordPeptide analoguesen
KeywordCanceren
KeywordMTT assayen
PublisherBrieflandsen
TitleDesign and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agentsen
TypeOriginal Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpr-18-1299.pdf
Size:
603.09 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF
Download

Collections

Iranian Journal of Pharmaceutical Research