Apoptotic and cytotoxicity effects of All Trans Retinoic Acid (ATRA) in cultured human uterine myoma

Abstract

Background: Uterine leiomyoma is the most common tumor among the female in the reproductive period. The first step to control the tumor is employing medical treatment. Currently GnRH agonists are the most common drugs for medical therapy of uterine myoma. Climacteric-like symptoms and osteoporosis and recurrence of the size of tumor after GnRH agonists consumption are among the most common side effects of employing the medical treatment. In the present study the apoptotic and cytotoxicity effects of All Trans Retinoic Acid (ATRA) on cultured human leiomyoma cells were investigated.