Histologic Evaluation of Normobaric Oxygen Therapy Safety in an Animal Model
| Author | Esmaeil Idani | en |
| Author | Nastaran Ranjbari | en |
| Author | Farideh Sharifipour | en |
| Author | Ali Asghar Hemmati | en |
| Author | Mohammad Malekahmadi | en |
| Issued Date | 2012-08-25 | en |
| Abstract | Background: Oxygen therapy, as a therapeutic modality, can be used for long periods of times. However, it may be accompanied by potential complications and side effects. Objectives: To evaluate the side effects of normobaric oxygen therapy in rabbits. Materials and Methods: In a double-blind experiment, 28 white New Zealand rabbits were randomized into an oxygen treatment group (n = 14) and a control group (n = 14).The oxygen treatment group received 100% oxygen at a flow rate of 5 L/min for 1 h daily,for 1 month. The animals were euthanized at the end of the study, and following autopsya histological evaluation was carried out to detect levels of oxygen toxicity in their; lungs, liver, brain, heart, kidney, eyes and spleen. Results: Histological evaluation revealed no evidence of toxicity in the examined tissues, compared with the control group. Conclusions: Oxygen therapy at a flow rate of 5 L/min for 1 h daily for 1 month had no systemic toxicity and it appears to be safe in rabbits. | en |
| DOI | https://doi.org/10.17795/jjnpp-3806 | en |
| Keyword | Safety | en |
| Keyword | Oxygen Inhalation Therapy | en |
| Keyword | Rabbits | en |
| Publisher | Brieflands | en |
| Title | Histologic Evaluation of Normobaric Oxygen Therapy Safety in an Animal Model | en |
| Type | Research Article | en |
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