Effect of Vitamin B3 on Iron and Plasma cortisol in Postpartum Depression in Female Mice
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Date
2018-10-31
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Brieflands
Abstract
Introduction: change in cortisol levels and low iron levels after childbirths one of the major factors that exacerbate postpartum depression in women. The B-vitamins as a supplement can be effective in treating this disorder. The aim of this study was to investigate the effect of The B3 vitamin on plasma cortisol and blood iron levels in postpartum depression in adult female mice.Materials and Methods: In this study, 50 female mice of NMRI strain were divided into 5 groups (n = 10) including the control group, postpartum depression group, and groups of postpartum depression and treatment with doses of 50, 100 and 200 mg/kg vitamin B3. The depression model was induced with a five days progesterone injection and its discontinuation. In the treated groups, vitamin B3 was injected intraperitoneally. The levels of iron and plasma cortisol in all experimental groups were measured and compared.Results: the results showed that the cortisol level in the postpartum depression group was significantly increased while the iron level was decreased. In the treated groups, all three doses of vitamin B3 have been shown to decrease cortisol levels and only 50 doses led to the increased iron levels.Conclusions: In the initial days after childbirth, taking vitamin B3 supplement can lead to reduced cortisol levels and depression in moms, and in order to avoid becoming deficient in iron, it is recommended that all animals take vitamin supplements, which requires further examination.