The Effect of Orally-Administered Zinc in the Prevention of Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia
| Author | Narges Gholizadeh | en |
| Author | Masoumeh Mehdipour | en |
| Author | Seyyed Hadi Chavoshi | en |
| Author | Sirvan Kahani | en |
| Author | Maryam-Sadat Sadrzadeh-Afshar | en |
| Orcid | Narges Gholizadeh [0000-0002-3231-1909] | en |
| Orcid | Maryam-Sadat Sadrzadeh-Afshar [0000-0001-8277-3805] | en |
| Issued Date | 2017-08-31 | en |
| Abstract | Background: Oral mucositis is a frequent yet serious adverse event associated with chemotherapy in acute myeloid leukemia. Although a wide spectrum of drugs has been tested for prophylaxis of oral mucositis, few of them are satisfactory. There is currently substantial clinical interest in zinc (Zn) as an antioxidant and a protective agent against chemotherapy -relatednormal tissue injury. Therefore, in the present study, we investigated whether zinc prevents oral mucositis associated with chemotherapy in patients with AML. Methods: A total of 140patients with AML were randomly selected and divided into two groups where the case groups received zinc sulfate 220 mg orally and the control groups received placeboes 3 times a day during their chemotherapy course. Data were analyzed by SPSS version 15 software. Mann-Whitney U test was used to evaluate mucositis, and pain intensity. Results: The incidence rates of mucositis were all markedly lower in oral zinc sulfate group than in control (P = 0.004). Conclusions: Zinc is available for preventing the complications of oral mucositis, and thus for improving patient quality of life. | en |
| DOI | https://doi.org/10.5812/ijcm.9252 | en |
| Keyword | Mucositis | en |
| Keyword | Leukemia | en |
| Keyword | Zinc Sulfate | en |
| Publisher | Brieflands | en |
| Title | The Effect of Orally-Administered Zinc in the Prevention of Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia | en |
| Type | Research Article | en |
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