Comparative Analysis of Clinical and Paraclinical Manifestations of Neonatal COVID-19 and Sepsis: A Study from Shiraz, Iran
| Author | Khadijeh Sadat Najib | en |
| Author | Alireza Salehi | en |
| Author | Deepak Sharma | en |
| Author | Shahnaz Pourarian | en |
| Author | Hamide Barzegar | en |
| Author | Mohammadreza Azangou-Khyavy | en |
| Author | Nazanin Farahbakhsh | en |
| Orcid | Khadijeh Sadat Najib [0000-0002-0094-0145] | en |
| Orcid | Alireza Salehi [0000-0003-2750-8499] | en |
| Orcid | Shahnaz Pourarian [0000-0002-7286-6108] | en |
| Orcid | Hamide Barzegar [0000-0003-1114-5937] | en |
| Orcid | Mohammadreza Azangou-Khyavy [0000-0002-4543-4633] | en |
| Orcid | Nazanin Farahbakhsh [0000-0003-4631-0955] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Neonates are particularly vulnerable to COVID-19, presenting with symptoms that may overlap with those seen in neonatal sepsis. Objectives: This study aims to compare the clinical and paraclinical manifestations of COVID-19 and sepsis in neonates. Methods: A cohort of 48 neonates diagnosed with either sepsis or COVID-19 between February 2020 and December 2020 at Namazi and Hafez hospitals in Shiraz, Iran, were included in this analysis. Clinical and paraclinical parameters were systematically recorded and analyzed. Results: Among the observed parameters, poor feeding (54.16% vs. 20.83%) and lethargy (33.33% vs. 8.33%) were significantly more prevalent in neonates with sepsis compared to those with COVID-19 (P = 0.01, 0.03). Blood cultures were positive in 100% of the sepsis group, while only 8.3% of COVID-19 cases showed positive blood cultures (P < 0.001). All urine cultures in COVID-19 cases were sterile, whereas 16.6% of neonates with sepsis had positive urine cultures (P = 0.29). Platelet counts were significantly lower in the sepsis group compared to COVID-19 group (199.08 ± 184.61 × 10³/mm³ vs. 296.73 ± 160.15 × 10³/mm³) (P = 0.03) and C-reactive protein (CRP) levels were notably higher in sepsis cases (96.83 ± 53.55 mg/dL vs. 29.14 ± 52.72 mg/dL) (P < 0.001). Radiological findings showed no significant differences between the groups. Neonatal mortality was higher in the COVID-19 group compared to the sepsis group (25% vs. 4.2%) (P = 0.35). Conclusions: This study reveals distinct clinical and paraclinical differences between neonatal COVID-19 and sepsis. Poor feeding and lethargy are more common in sepsis, and neonates with sepsis exhibit higher rates of positive cultures and worse hematologic parameters compared to those with COVID-19. These findings underscore the need for early differential diagnosis and tailored management strategies in neonatal infectious diseases. | en |
| DOI | https://doi.org/10.5812/archcid-148815 | en |
| Keyword | Infant | en |
| Keyword | COVID-19 | en |
| Keyword | Neonate | en |
| Keyword | Newborn | en |
| Keyword | Sepsis | en |
| Publisher | Brieflands | en |
| Title | Comparative Analysis of Clinical and Paraclinical Manifestations of Neonatal COVID-19 and Sepsis: A Study from Shiraz, Iran | en |
| Type | Research Article | en |
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