Short-Term Comparative Study of the Cyclophosphamide Genotoxicity Administered Free and LiposomeEncapsulated in Mice
| Author | Ehab Abdella | en |
| Issued Date | 2012-06-30 | en |
| Abstract | Background: Cyclophosphamide (CYP) is used to treat a wide range of human tumors. However, the mutagenic effect of CYP is still the primary limitation for wider applications to treat a variety of human malignancies. It has been reported that CYP entrapped in liposomes reduces non-specific toxicity and enhances anticancer effects in animal systems. Methods: In the present experiment, mice were injected with 50 mg/kg free CYP or encapsulated in liposomes to compare their ability to induce mutagenic damages including chromosomal aberrations, changes in Sister Chromatid Exchange (SCEs) frequencies, and in Mitotic Index (MI), as well as in cell cycle kinetics. | en |
| DOI | https://doi.org/ | en |
| Keyword | Cyclophosphamide | en |
| Keyword | Liposome-encapsulated | en |
| Keyword | Genotoxicity | en |
| Keyword | Sister Chromatid Exchanges | en |
| Keyword | Mice | en |
| Publisher | Brieflands | en |
| Title | Short-Term Comparative Study of the Cyclophosphamide Genotoxicity Administered Free and LiposomeEncapsulated in Mice | en |
| Type | Research Article | en |
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