The Role of Aflatoxins in Hepatocellular Carcinoma
| Author | Hui-Chen Wu | en |
| Author | Regina Santella | en |
| Issued Date | 2012-10-01 | en |
| Abstract | Context: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world but with a striking geographical variation in incidence; most of the burden is in developing countries. This geographic variation in HCC incidence might be due to geographic differences in the prevalence of various etiological factors. Evidence Acquisition: Here, we review the epidemiological evidence linking dietary exposure to aflatoxin B1 (AFB1) and risk of HCC, possible interactions between AFB1 and hepatitis B virus (HBV) or polymorphisms of genes involved in AFB1-related metabolism as well as DNA repair. Results: Ecological, case-control and cohort studies that used various measures of aflatoxin exposure including dietary questionnaires, food surveys and biomarkers are summarized. Conclusions: Taken together, the data suggest that dietary exposure to aflatoxins is an important contributor to the high incidence of HCC in Asia and sub-Saharan Africa, where almost 82% of the cases occur. | en |
| DOI | https://doi.org/10.5812/hepatmon.7238 | en |
| Keyword | Aflatoxins | en |
| Keyword | Aflatoxin-albumin Adducts | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Hepatocellular Carcinoma | en |
| Publisher | Brieflands | en |
| Title | The Role of Aflatoxins in Hepatocellular Carcinoma | en |
| Type | Review Article | en |