Crocin-Induced Endothelium-Dependent Relaxation in Isolated Rat Aorta
| Author | Bibi Marjan Razavi | en |
| Author | Meysam Seydali Seyfabad | en |
| Author | Hossein Hosseinzadeh | en |
| Author | Mohsen Imenshahidi | en |
| Issued Date | 2017-05-31 | en |
| Abstract | Background: Crocin, an active ingredient of saffron, has been found to possess hypotensive effects. Objectives: The aim of this study was to evaluate the mechanism of vasodilatory effects induced by crocin on isolated rat aorta. Methods: To study the vasodilatory effects of crocin (0.1, 0.2, 0.4 and 0.8 M), isolated rat thoracic aorta rings were contracted by 10-6 M Phenylephrine (PE) or 80 mM of KCl. To assess the role of nitric oxide in mechanism of relaxation, induced by crocin, aortic rings were incubated by L-NG-Nitroarginine methyl ester (L-NAME: 10-6 M) for 20 minutes. Furthermore, the relaxant effect of crocin was evaluated both in intact and denuded endothelium aortic rings. Results: Crocin induced relaxation in endothelium-intact aortic rings precontracted with PE in a concentration dependent manner yet not in KCl precontracted aortic rings. The relaxant activity of crocin was abolished by incubation of aortic rings with L-NAME. In addition, the endothelium removal inhibited the relaxant activity of crocin. Conclusions: This study indicated that relaxant activity of crocin is mainly mediated through an endothelium-dependent mechanism. | en |
| DOI | https://doi.org/10.5812/jjnpp.32801 | en |
| Keyword | <i>Crocus sativus</i> L. | en |
| Keyword | Isolated Rat Aorta | en |
| Keyword | L-NAME | en |
| Keyword | Hypertension | en |
| Publisher | Brieflands | en |
| Title | Crocin-Induced Endothelium-Dependent Relaxation in Isolated Rat Aorta | en |
| Type | Research Article | en |
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