Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy
| Author | Gian Paolo Caviglia | en |
| Author | Maria Lorena Abate | en |
| Author | Paola Manzini | en |
| Author | Franca Danielle | en |
| Author | Alessia Ciancio | en |
| Author | Chiara Rosso | en |
| Author | Antonella Olivero | en |
| Author | Rinaldo Pellicano | en |
| Author | Giovanni Antonio Touscoz | en |
| Author | Antonina Smedile | en |
| Author | Mario Rizzetto | en |
| Orcid | Alessia Ciancio [0000-0003-3438-0649] | en |
| Orcid | Rinaldo Pellicano [0000-0003-3438-0649] | en |
| Orcid | Giovanni Antonio Touscoz [0000-0003-3438-0649] | en |
| Orcid | Antonina Smedile [0000-0003-3438-0649] | en |
| Orcid | Mario Rizzetto [0000-0003-3438-0649] | en |
| Issued Date | 2012-11-01 | en |
| Abstract | Background: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the liver and/or in the serum of patients with negative results of hepatitis B s antigen (HBsAg) test with or without serological markers of previous viral exposure. The impact of OBI in patients with chronic hepatitis C (CHC) is still unclear. Objectives: The Aim of this study was to assess OBI prevalence and its potential implications on treatment outcome in a cohort of patients with CHC underwent standard antiviral therapy. Patients and Methods: Baseline serum samples from 137 HBsAg-negative CHC patients treated with pegylated-interferon and ribavirin (73 Responders/74 Non Responders),were retrospectively analyzed for HBV status. Results: Seventy-three patients (53.3%) showed markers of previous exposure to HBV. HBV DNA was detected in 2 of 137 serum samples (1.5%), both carrying HBV antibodies. Liver biopsies and post-therapy sera were available for 35 patients (12 Responders/23 Non Responders). HBV DNA sequences were found in 13 of 35 specimens (37.1%), all of patients with HBV DNA negativity in basal and post-therapy serum samples. Among OBI-positive patients, 5 (38.5%) carried serological markers of HBV infection. Regarding therapy outcome, in the OBI-positive group there were 5 of 13 (38.5%) sustained virological responders (SVR) compared to 7 of 22 (31.8%) in the OBI-negative one. Conclusions: Despite the high prevalence rate of liver HBV DNA in patients with CHC, SVR was not affected by occult HBV infection. | en |
| DOI | https://doi.org/10.5812/hepatmon.7292 | en |
| Keyword | Hepatitis C | en |
| Keyword | Chronic | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Infection | en |
| Publisher | Brieflands | en |
| Title | Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy | en |
| Type | Research Article | en |
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