Therapeutic Efficacy of Hydrochlorothiazide in Primary Monosymptomatic Nocturnal Enuresis in Boys With Idiopathic Hypercalciuria
| Author | Parsa Yousefichaijan | en |
| Author | Mojtaba Sharafkhah | en |
| Author | Ali Cyrus | en |
| Author | Mohawmmad Rafeie | en |
| Issued Date | 2015-09-01 | en |
| Abstract | Background: Idiopathic hypercalciuria (IHC) can be one of the causes of nocturnal enuresis (NE) and hydrochlorothiazide (HCT) ameliorates hypercalciuria. Objectives: The aim of this study was to assess the therapeutic efficacy of HCT in boys with primary monosymptomatic NE (PMNE). Patients and Methods: This study was a randomized double-blind placebo-controlled clinical trial. A hundred boys with PMNE and IHC were randomly assigned into two groups of experimental (treated with HCT 1 mg/kg/day) and control and all patients were followed for 4 months for the number of wet-night episodes. Results: The mean numbers of wet-night episodes in the first (intervention: 8.34 ± 8.54, control: 9.1 ± 9.3, P = 0.3), second (7.1 ± 7.3, 7.9 ± 8.1, P = 0.4), third (7.8 ± 8, 7.9 ± 8.1, P = 0.1) and fourth (4.9 ± 5.1, 5.9 ± 6, P = 0.3) months were not significantly different between the two groups. However, the decrease in the average wet-night episodes during the 4 months of treatment in the intervention group (P = 0.019) unlike the control group. Not more significant compared to control group (P = 0.191). All patients who were treated by HCT became normocalciuric. However, in 21 patients the dose was increased to 2 mg/kg/day. Conclusions: Single daily dose of HCT is a safe and effective therapeutic option in the treatment of PMNE in children with IHC. | en |
| DOI | https://doi.org/10.5812/numonthly.29127 | en |
| URI | https://brieflands.com/journals/num/articles/17213 | en |
| Keyword | Nocturnal Enuresis | en |
| Keyword | Hypercalciuria | en |
| Keyword | Hydrochlorothiazide | en |
| Keyword | Child | en |
| Publisher | Brieflands | en |
| Title | Therapeutic Efficacy of Hydrochlorothiazide in Primary Monosymptomatic Nocturnal Enuresis in Boys With Idiopathic Hypercalciuria | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 17213-pdf.pdf
- Size:
- 214.05 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF