Analysis of routine and novel sperm selection methods for the treatment of infertile patients undergoing ICSI procedure

Abstract

Background: Successful outcome of Assisted Reproductive Techniques (ART) depends on many factors such as sperm preparation methods, embryo quality and factors that may affect implantation. In Intra-cytoplasmic Sperm Injection (ICSI), sperm selection is mainly based on sperm motility and morphology; however, studies have revealed that these parameters cannot guarantee the genomic health. Recently, researchers and scientific have focused on new sperm selection methods based on cellular and molecular properties. Therefore, the aim of this review article was to introduce the routine and novel sperm selection methods, advantages and disadvantages of these methods, and their clinical analysis.