Hepatoprotective Effect of <i>Otostegia persica</i> Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats
| Author | Sedighe Nasiri Bezenjani | en |
| Author | Iran Pouraboli | en |
| Author | Reza Malekpour Afshar | en |
| Author | Gholamabbas Mohammadi | en |
| Issued Date | 2012-10-31 | en |
| Abstract | In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract of O. persica shoot (in 200, 300, 400 mg/Kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (MDA), transaminase enzyme levels in plasma [aspartate transaminase (AST), alanine aminotransferase (ALT)] and liver glutathione (GSH) levels). Results show that the methanol extract of O. persica shoot is active at 300 mg/Kg (per os) and it possess remarkable antioxidant and hepatoprotective activities. Additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1174 | en |
| Keyword | <i>Otostegia persica</i> | en |
| Keyword | Hepatoprotective | en |
| Keyword | Carbon tetrachloride | en |
| Keyword | Histopathology | en |
| Keyword | MDA | en |
| Keyword | GSH | en |
| Publisher | Brieflands | en |
| Title | Hepatoprotective Effect of <i>Otostegia persica</i> Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats | en |
| Type | Original Article | en |