Single Layer Extended Release Two-in-One Guaifenesin Matrix Tablet: Formulation Method, Optimization, Release Kinetics Evaluation and Its Comparison with Mucinex<sup>®</sup> Using Box-Behnken Design
| Author | Amirhosein Morovati | en |
| Author | Alireza Ghaffari | en |
| Author | Lale Erfani jabarian | en |
| Author | Ali Mehramizi | en |
| Issued Date | 2017-10-31 | en |
| Abstract | Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug. Owing to its poor flowability and compressibility, formulating tablets especially high-dose one, may be a challenge. Direct compression may not be feasible. Bilayer tablet technology applied to Mucinex®, endures challenges to deliver a robust formulation. To overcome challenges involved in bilayer-tablet manufacturing and powder compressibility, an optimized single layer tablet prepared by a binary mixture (Two-in-one), mimicking the dual drug release character of Mucinex® was purposed. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2144 | en |
| Keyword | Binary mixture | en |
| Keyword | Bilayer tablets | en |
| Keyword | High dose modified release tablets | en |
| Keyword | Highly water-soluble drug | en |
| Keyword | Poor compressibility | en |
| Publisher | Brieflands | en |
| Title | Single Layer Extended Release Two-in-One Guaifenesin Matrix Tablet: Formulation Method, Optimization, Release Kinetics Evaluation and Its Comparison with Mucinex<sup>®</sup> Using Box-Behnken Design | en |
| Type | Original Article | en |