IL-17 Producing T cells as Predictors of Primary Immunodeficiencies in Patients with <i>Candida</i> Infections
| Author | Mehrdad Amirmoeini | en |
| Author | Zahra Chavoshzadeh | en |
| Author | Arezou Rahimi | en |
| Author | Mohammad Nabavi | en |
| Author | Seyed Alireza Mahdaviani | en |
| Author | Shahnaz Armin | en |
| Author | Sepideh Darougar | en |
| Author | Mehrnaz Mesdaghi | en |
| Orcid | Zahra Chavoshzadeh [0000-0003-1869-8630] | en |
| Orcid | Mohammad Nabavi [0000-0001-6558-0390] | en |
| Orcid | Seyed Alireza Mahdaviani [0000-0001-6224-4797] | en |
| Orcid | Shahnaz Armin [0000-0002-4993-482X] | en |
| Orcid | Sepideh Darougar [0000-0003-1399-8351] | en |
| Issued Date | 2022-05-19 | en |
| Abstract | Background: IL-17 producing T cells are a distinct subset of CD4+ T cells, which are recognized to have an essential role in protection against certain fungi and extracellular pathogens. Objectives: This study aims to evaluate the number of IL-17 producing T cells as a predictor of primary immunodeficiency disorders in patients with Candida infections and low numbers of IL-17 producing T cells. Methods: Seven newly diagnosed patients with documented Candida infections aged between 4 and 35 years were included in this study. Before establishing the diagnosis of chronic mucocutaneous candidiasis, a thorough immunodeficiency workup, including complete blood count, serum Ig levels and antibody responses, flow-cytometry evaluation, and LTT, was completed for all the patients, and other immunodeficiency disorders, including combined and phagocytic deficiencies, were ruled out. Then, IL-17 producing T cells were detected using antiCD3 and anti-IL-17 antibodies through flow-cytometry evaluation. Results: The IL-17 producing T cells significantly decreased in the peripheral blood of patients with PID and candida infections. A P-value of less than 0.05 was considered statistically significant. Conclusions: To conclude, in cases of recurrent candida infections, initial assessment of IL-17 producing T cells may act as a predictor of an underlying primary immunodeficiency. In patients with low counts of IL-17 producing T cells, selecting a targeted panel of genetic tests may become more helpful in the detection of certain immunodeficiency disorders than performing whole-exome sequence analysis. | en |
| DOI | https://doi.org/10.5812/pedinfect-113894 | en |
| Keyword | IL-17 Producing T Cells | en |
| Keyword | Primary Immunodeficiency | en |
| Keyword | <i>Candida</i> | en |
| Publisher | Brieflands | en |
| Title | IL-17 Producing T cells as Predictors of Primary Immunodeficiencies in Patients with <i>Candida</i> Infections | en |
| Type | Research Article | en |
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