Influence of nicotine and nitric oxide in the nucleus accumbens on ethanol state-dependent learning
| Author | Azam Moshfegh | en |
| Author | Nasrin Raufi | en |
| Author | Maryam-sadat Shahin | en |
| Author | M [email protected] | en |
| Issued Date | 2014-03-31 | en |
| Abstract | Introduction: Nitric oxide synthase enzyme has been detected in the Nucleus accumbens, which is the targetareas of the mesolimbic dopamine pathways. In the present study, the effect of intra-NAc administration of the nitric oxide precursor was investigated on nicotine’s effects in ethanol state-dependent learning. Materials and Methods: Rats were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and two stainless-steel cannuale were placed 2 mm above nucleus accumbens of them. One week later, the animals were trained in a step-through type inhibitory avoidance task. On the test day step-through latency was measured for the assessment of memory in male Wistar rats. Results: Pre-training injection of ethanol induced amnesia (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Nitric oxide, Nicotine, Nucleus accumbens, Learning/drug effect, Memory/drug effects, Ethanol, Rat | en |
| Keyword | اکسید نیتریک، نیکوتین، هسته اکومبنس، یادگیری/اثرات دارویی، حافظه/اثرات دارویی، اتانول، موشهای صحرایی | en |
| Publisher | Brieflands | en |
| Title | Influence of nicotine and nitric oxide in the nucleus accumbens on ethanol state-dependent learning | en |
| Type | Research Article | en |
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