Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran
| Author | Zohreh Rahimi | en |
| Author | Amin Gravand | en |
| Author | Habibolah Khazaie | en |
| Author | Sahar Mohammadi | en |
| Author | Ziba Rahimi | en |
| Author | Asad Vaisi-Raygani | en |
| Author | Ebrahim Shakiba | en |
| Orcid | Zohreh Rahimi [0000-0001-7589-3307] | en |
| Orcid | Habibolah Khazaie [0000-0002-8066-9753] | en |
| Issued Date | 2016-12-31 | en |
| Abstract | Background: Brain-derived neurotrophic factor (BDNF) might involve in the pathogenesis of mental disorders. There are inconsistent reports related to the role of BDNF Val66Met in susceptibility to bipolar disorder (BD). Objectives: The aim of the present study was to investigate the role of BDNF Val66Met and its synergism with 5-HTT gene-linked polymorphic region (5-HTTLPR) variants in susceptibility to bipolar I disorder (BP-I) in Western Iran. Materials and Methods: In this case-control study, 153 patients with BP-I and 146 age- and gender-matched healthy individuals were investigated for BDNF and 5-HTTLPR variants using PCR-RFLP method. Results: The frequency of BDNF A (Met) allele in patients (17.7%) was slightly lower than that in controls (19.9%, P = 0.5). The concomitant presence of BDNF G (Val) and 5-HTTLPR S alleles tended to increase the risk of BP-I by 1.41 times (P = 0.064) compared to the combined presence of BDNF G and 5-HTTLPR L alleles. Also, interaction between BDNF G (Val) and 5-HTTLPR S tended to increase the risk of BP-I by 1.28-fold (P = 0.062) compared to the concomitant presence of BDNF A and 5-HTTLPR S alleles. Conclusions: This study, conducted for the first time on Kurdish population in Western Iran, did not indicate any association between BDNF Val66Met with BP-I. However, the interaction between BDNF and 5-HTTLPR variants tended to increase the susceptibility to BP-I. | en |
| DOI | https://doi.org/10.17795/ijpbs-5173 | en |
| Keyword | Bipolar I Disorder | en |
| Keyword | Brain-Derived Neurotrophic Factor Val66Met | en |
| Keyword | Polymorphism | en |
| Keyword | Serotonin Transporter Gene | en |
| Keyword | Synergism | en |
| Keyword | 5-HTTLPR | en |
| Publisher | Brieflands | en |
| Title | Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran | en |
| Type | Research Article | en |
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