HE4 and Risk Factors of Endometrial Cancer in Women with Abnormal Uterine Bleeding; Application of Accelerated Failure Time Models
| Author | Hassan Karimi | en |
| Author | Mona Khorami | en |
| Author | Alireza Solimanzadeh | en |
| Author | Elham Shafiei | en |
| Author | Hosein Seidkhani | en |
| Author | Razhan Chehreh | en |
| Orcid | Elham Shafiei [0000-0001-5689-5235] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Endometrial cancer (EC) is the leading cause of death from gynecologic cancers. Objectives: This study was executed to estimate the role of human epididymal protein 4 (HE4) levels in the prognosis and follow-up of EC. Methods: This registry-based, single-center retrospective cohort study was conducted on women with abnormal uterine bleeding (AUB) between March 15, 2022, and September 15, 2023, at a university hospital in Ilam, southwest Iran. The study applied accelerated failure time (AFT) models to a dataset of 38 women with AUB. Model performance was evaluated using Akaike’s information criterion (AIC) and visual assessment of Cox-Snell residuals. The HE4 concentrations > 140 g/L at admission were considered predictive of ovarian tumors. Results: In the adjusted model, the results of the Weibull model showed that HE4 (adjusted time ratio; 1.89 (95% CI: 1.30 - 2.19; P < 0.001) was the accelerated factor for progression to EC in women with AUB. Conclusions: Serum HE4 dosage seems to be a useful preoperative test for predicting EC outcomes in women with AUB. | en |
| DOI | https://doi.org/10.5812/ijcm-149040 | en |
| URI | https://brieflands.com/journals/ijcm/articles/149040 | en |
| Keyword | Human Epididymis Protein 4 | en |
| Keyword | HE4 | en |
| Keyword | Endometrial Cancer | en |
| Keyword | Prognostic Marker | en |
| Publisher | Brieflands | en |
| Title | HE4 and Risk Factors of Endometrial Cancer in Women with Abnormal Uterine Bleeding; Application of Accelerated Failure Time Models | en |
| Type | Research Article | en |
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