A Clinical Trial on the Effects of Different Regimens of Phenylephrine on Maternal Hemodynamic After Spinal Anesthesia for Cesarean Section
| Author | Mahshid Nikooseresht | en |
| Author | Mohammad Ali Seifrabiei | en |
| Author | Pouran Hajian | en |
| Author | Shadab Khamooshi | en |
| Orcid | Mahshid Nikooseresht [0000-0003-4482-6587] | en |
| Orcid | Mohammad Ali Seifrabiei [0000-0002-5443-7115] | en |
| Orcid | Pouran Hajian [0000-0002-3086-717X] | en |
| Issued Date | 2020-07-19 | en |
| Abstract | Background: Phenylephrine is used to prevent and treat hypotension during spinal anesthesia for cesarean delivery. Objectives: The present study aims to investigate the effects of different regimens of phenylephrine on blood pressure of candidates for the cesarean section. Methods: In this double-blind, randomized clinical trial, a total of 120 candidates of elective cesarean delivery under spinal anesthesia was randomly categorized into three groups. Groups 1, 2, and 3 received bolus and prophylactic saline (control group), prophylactic bolus phenylephrine (100 µg), and prophylactic phenylephrine infusion (50 µg/min), respectively. The incidence of hypotension, maternal hemodynamics, hypertension, rescue phenylephrine dose, nausea, and vomit were compared between the groups. Results: In all the three groups, the incidence of nausea and vomit, bradycardia, hypertension, and neonatal Apgar score were not statistically different (P > 0.05). However, the adjuvant phenylephrine dose requirement was remarkably different. Moreover, the mean systolic blood pressure differed significantly in the second and 7th minutes after the spinal block (P < 0.05). 35% in the first group, 15% in the second group, and 2.5% in the third group had hypotension (P = 0.001). Apart from the first measurement after spinal anesthesia, the mean heart rate showed no significant difference between the groups. Conclusions: The use of prophylactic phenylephrine infusion is recommended to control the optimal blood pressure in parturients undergoing cesarean section after spinal anesthesia. | en |
| DOI | https://doi.org/10.5812/aapm.58048 | en |
| Keyword | Spinal Anesthesia | en |
| Keyword | Hypotension | en |
| Keyword | Cesarean | en |
| Keyword | Phenylephrine | en |
| Publisher | Brieflands | en |
| Title | A Clinical Trial on the Effects of Different Regimens of Phenylephrine on Maternal Hemodynamic After Spinal Anesthesia for Cesarean Section | en |
| Type | Research Article | en |
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