Antioxidant, Antiglycation and Anti-Hyperlipidemic Effects of <i>Trigonella foenum</i> and Cinnamon in Type 2 Diabetic Rats
| Author | Seyed Mehrdad Kassaee | en |
| Author | Mohammad Taghi Goodarzi | en |
| Author | Ebrahim Abbasi Oshaghi | en |
| Issued Date | 2018-02-28 | en |
| Abstract | Background: Diabetes is recognized as a common metabolic disorder, which is treated by different medicines. Objectives: The aim of this study was to study the effect of Trigonella foenum and Cinnamon on glycation, some biochemical factors, liver histology and cholesterol 7-alpha hydroxylase activity in type 2 diabetic rats. Methods: Antiglycation and antioxidant ability were determined in vitro. Male Wistar diabetic rats were treated by 2 and 8% of Cinnamon (w/w) and Trigonella foenum. Biochemical factors and liver enzymes were measured using enzymatic spectrophotometric methods. Lipase and cholesterol 7-alpha hydroxylase activity were determined. Liver lipid, antioxidant and morphological change were assessed. Results: Different concentrations of these plants (0.032, 0.065, 0.125, 0.25, 0.5 and 1mg/ mL) showed potential antiglycation ability. Cinnamon and Trigonella foenum significantly reduced advanced glycosylation end products (AGEs) and fructosamine formation, and also declined protein carbonyl contents and thiol group’s oxidation (P < 0.001). Cinnamon and Trigonella foenum extract in Streptozotocin (STZ)-induced diabetic rat normalized antioxidant capacity and lipid profile (P < 0.001). The cholesterol 7-alpha hydroxylase activity significantly increased following these plants administration. Also, the liver histopathological changes were normalized in diabetic rats treated by Cinnamon and Trigonella foenum extract. Conclusions: The findings illustrated that Cinnamon and Trigonella foenum extract improved hyperlipidemia and hyperglycemic. The hypolipidemic effect was likely by motivation of cholesterol 7-alpha hydroxylase activity. These plants also showed significant anti-diabetic effects in animal model by reducing blood glucose and inhibition of AGEs and fructosamine formation. | en |
| DOI | https://doi.org/10.8512/jjnpp.38414 | en |
| Keyword | Cinnamon | en |
| Keyword | Cholesterol 7-alpha Hydroxylase | en |
| Keyword | Herbal Medicine | en |
| Keyword | Trigonella Foenum | en |
| Keyword | Type 2 Diabetes | en |
| Publisher | Brieflands | en |
| Title | Antioxidant, Antiglycation and Anti-Hyperlipidemic Effects of <i>Trigonella foenum</i> and Cinnamon in Type 2 Diabetic Rats | en |
| Type | Research Article | en |