Anti-inflammatory Properties of the Genus <i>Symphytum</i> L.: A Review
| Author | Elaheh Mahmoudzadeh | en |
| Author | Hossein Nazemiyeh | en |
| Author | Sanaz Hamedeyazdan | en |
| Orcid | Elaheh Mahmoudzadeh [0000-0003-1333-6358] | en |
| Orcid | Hossein Nazemiyeh [0000-0003-0165-3209] | en |
| Orcid | Sanaz Hamedeyazdan [0000-0002-8950-9879] | en |
| Issued Date | 2022-12-31 | en |
| Abstract | The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language were gathered from 2000 to 2021. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The Symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action. | en |
| DOI | https://doi.org/10.5812/ijpr.123949 | en |
| Keyword | Inflammation | en |
| Keyword | Boraginacea | en |
| Keyword | Comfrey | en |
| Keyword | Wound Healing | en |
| Keyword | Arthritis | en |
| Keyword | Rheumatoid | en |
| Publisher | Brieflands | en |
| Title | Anti-inflammatory Properties of the Genus <i>Symphytum</i> L.: A Review | en |
| Type | Review Article | en |