Association of Ankle-Brachial Index with Coronary Artery Disease Burden in Patients with Type 2 Diabetes and Stable Angina
| Author | Mehdi Pishgahi | en |
| Author | Mahtab Niroomand | en |
| Author | Seyedeh Parisa Tahazadeh | en |
| Orcid | Mehdi Pishgahi [0000-0002-1196-6535] | en |
| Orcid | Mahtab Niroomand [0000-0001-7463-9366] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Type 2 diabetes mellitus (T2DM) is a well-established major risk factor for the development and progression of coronary atherosclerosis. The Ankle-Brachial Index (ABI) is a simple, non-invasive tool used to assess peripheral artery disease (PAD) and has been proposed as a marker of systemic atherosclerosis. Objectives: The present study aimed to examine the association between ABI values and the severity and extent of coronary atherosclerosis in patients with T2DM presenting with stable angina pectoris. Methods: In this cross-sectional study, 180 patients with T2DM who underwent coronary angiography for stable angina between 2022 and 2024 were enrolled. Demographic, clinical, and laboratory data were recorded. The ABI was measured using a standard Doppler technique, and the SYNTAX score was calculated based on coronary angiography findings. Results: Abnormal ABI (≤ 0.9 or > 1.4) was observed in 23.1% of patients. Patients with abnormal ABI were significantly older, had higher HbA1c levels, a higher prevalence of hypertension and smoking history, and significantly higher SYNTAX scores compared to those with normal ABI (all P < 0.05). A strong inverse correlation was found between ABI values and SYNTAX score in the entire cohort (R = -0.58, P < 0.001), which remained significant even in the subgroup with abnormal ABI. In multivariable linear regression analysis, low ABI, elevated LDL-cholesterol, hypertension, and higher HbA1c were identified as independent predictors of higher SYNTAX score (all P < 0.05). Conclusions: Given its simplicity, low cost, and non-invasive nature, ABI measurement can serve as a valuable bedside tool to identify diabetic patients at higher risk of advanced coronary artery disease (CAD). | en |
| DOI | https://doi.org/10.69107/intjcardiovascpract-168409 | en |
| URI | https://brieflands.com/journals/ijcp/articles/168409 | en |
| Keyword | Type 2 Diabetes Mellitus | en |
| Keyword | Ankle-Brachial Index (ABI) | en |
| Keyword | SYNTAX Score | en |
| Keyword | Coronary Atherosclerosis | en |
| Keyword | Stable Angina Pectoris | en |
| Publisher | Brieflands | en |
| Title | Association of Ankle-Brachial Index with Coronary Artery Disease Burden in Patients with Type 2 Diabetes and Stable Angina | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijcp-10-2-168409-publish-pdf.pdf
- Size:
- 320.48 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF