Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats

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AuthorEhsan Fattahianen
AuthorValiollah Hajhashemien
AuthorMohammad Rabbanien
AuthorMohsen Minaiyanen
AuthorParvin Mahzounien
Issued Date2016-03-31en
AbstractDepressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Then Amitriptyline (5, 10, 20 mg/kg, i.p.) was administered to separate groups of male Wistar rats. All treatments were carried out two hours after colitis induction and continued daily for four days. Dexamethasone (1 mg/kg) and normal saline (1 mL/kg) were used in reference and control groups, respectively. At day five, animals were euthanized and colonic tissue injuries were assessed macroscopically and pathologically. Myeloperoxidase activity as a marker of neutrophil infiltration was also measured in colonic tissues. Results showed that reserpine (6 mg/kg, i.p.) intensified colitic condition. Compared to control, amitriptyline (10, 20 mg/kg) and dexamethasone significantly decreased weight of colon and ulcer index in normal and reserpine-induced depressed rats. Myeloperoxidase activity and pathological assessments also proved anti-inflammatory effect of amitriptyline.en
DOIhttps://doi.org/10.22037/ijpr.2016.1813en
KeywordUlcerative colitisen
KeywordAcetic aciden
KeywordDepressive disordersen
KeywordAmitriptylineen
KeywordReserpineen
KeywordRatsen
PublisherBrieflandsen
TitleAnti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Ratsen
TypeOriginal Articleen

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Iranian Journal of Pharmaceutical Research