Effect of Quercetin on RAC1 Gene Expression as a Marker of Metastasis in Cervical Cancer Cells
| Author | Arezu Chakerzehi | en |
| Author | Neda Eivazi Arvanagh | en |
| Author | Samaneh Saedi | en |
| Author | Mahdiyeh Hematti | en |
| Author | Javad Mohiti Ardakani | en |
| Author | Ali Moradi | en |
| Author | Abolfazl Shokouhi | en |
| Issued Date | 2015-05-31 | en |
| Abstract | Background:: Cancer metastasis is the most important cause of cancer death and different treatment strategies have targeted on preventing the occurrence of metastasis. Quercetin is a flavonoid and widely used as an antioxidant and recent studies have discovered its anticancer and antiproliferative capabilities. Rac1 is protein known to involve in tumor invasion and metastases. Objectives:: In this study, we investigated the effect of quercetin on expression of Rac1 protein. Materials and Methods:: In this experimental study, HeLa cells were treated with quercetin at 2 concentrations (20 and 40 μM) for 24 hours and then cell lysate was assessed by Western blotting analysis to investigate the impact of quercetin on expression of Rac1 protein. Results:: Quercetin significantly decreased Rac1 expression of HeLa cells assessed by western blotting, in dose-dependent manners (P < 0.05). Conclusions:: This study showed that quercetin decreased Rac1 expression as a marker of metastasis in cervical cancer cells. Therefore, the quercetin may provide an effective new strategy to reduce of tumor metastasis. | en |
| DOI | https://doi.org/10.17795/zjrms962 | en |
| Keyword | Cervical cancer | en |
| Keyword | Quercetin | en |
| Keyword | Rac1 protein | en |
| Keyword | Metastasis | en |
| Keyword | HeLa cell | en |
| Publisher | Brieflands | en |
| Title | Effect of Quercetin on RAC1 Gene Expression as a Marker of Metastasis in Cervical Cancer Cells | en |
| Type | Research Article | en |
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