Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats.
| Author | Hoda Bahmanof | en |
| Author | Simin Dadashzadeh | en |
| Author | Afshin Zarghi | en |
| Author | Alireza Shafaati | en |
| Author | Seyed Mohsen Foroutan | en |
| Issued Date | 2017-04-30 | en |
| Abstract | Coxibs such as celecoxib, rofecoxib, and valdecoxib are introduced as selective COX-2 inhibitors to the market. It has been reported that inhibition of COX-2 beside traditional effects of NSAIDs, reduces the risk of colorectal, breast and lung cancers and also slow the progress of Alzheimer’s disease. Zarghi et al. reported 8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 102) as a novel compound with similar IC50 to celecoxib besides improved selectivity index (COX-1/COX-2 inhibitory potency) in comparison with celecoxib. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2055 | en |
| Keyword | Pharmacokinetic | en |
| Keyword | Sex-dependent | en |
| Keyword | Ketoprofen | en |
| Keyword | Selective COX-2 inhibitors | en |
| Keyword | AZGH 102 | en |
| Publisher | Brieflands | en |
| Title | Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats. | en |
| Type | Original Article | en |
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