Advances in Management Methods for Convulsive Status Epilepticus in Children: A Review of Iran Algorithms
| Author | Yasaman Ramezankhani | en |
| Issued Date | 2025-04-30 | en |
| Abstract | Context: As a common disorder, convulsive status epilepticus (CSE) in adults is second common and in children is most common neurological emergency. Morbidity of this condition such as difficulties of learning, de-novo epilepsy and neuro-disability, could be more than twenty two percent. The higher CSE duration led to higher difficulty to terminate this condition, and increase risk of morbidity. Evidence Acquisition: Convulsive status epilepticus is often managed by specific local or national algorithms. Treatment in first line is used when a focal motor clonic or tonic clonic seizure has duration more than five minutes (premonitory or impending CSE). In casese who CSE persisted with 2 first-line doses (difiened as CSE that is established), the second-line is administered. Different evidence of randomised clinical trial (RCT) supports benzodiazepines use as first-line drug. In addition alternative drugs, with less data of RCT studies, are intravenous clonazepam and intramuscular midazolam. Results: Up until 2019, phenytoin and phenobarbital were preferable second-line drug, but there are not significant RCT data about it. Also, lacosamide is alternative second-line agent but without supporting evidence from RCT studies. Current data showed that first, intravenous lorazepam or intranasal or buccal midazolam are most effective first-line drug to manage premonitory or impending CSE there are not diversity between effectiveness of phenytoin, sodium valproate or levetiracetam, for management of established CSE. Conclusions: In present review study, we give a general overview of status epilepticus and evaluate algorithms therapy in Iran. | en |
| DOI | https://doi.org/10.5812/zjrms-159110 | en |
| Keyword | Anticonvulsants | en |
| Keyword | Status Epilepticus | en |
| Keyword | Convulsive | en |
| Keyword | Anti-seizure Medications | en |
| Keyword | Emergency | en |
| Keyword | Children | en |
| Keyword | Pediatric | en |
| Publisher | Brieflands | en |
| Title | Advances in Management Methods for Convulsive Status Epilepticus in Children: A Review of Iran Algorithms | en |
| Type | Review Article | en |
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