Cardiovascular effects of five native plants from southern of Khorasan State

Abstract

Background: Traditionally, medicinal plants have been used to treat many diseases. To investigate the effects of different plants extract on cardiovascular system, five native southern Khorasan plants were used. Different concentration from the decoction of ziziphora, achillea millefolium (A.M) and aqueous extract of valeriana officinalis (V.O), viola and peganum harmala (P.H) were made. Methods and Materials: Animals, Male Sprague Dawley rats (200-250 g, n=25) were anaesthetized with sodium thiopental (30 mg/kg, i.p.), then systemic arterial blood pressure (systolic, diastolic and mean) was measured. Results: Mean arterial blood pressure was 140 ± 5 mmHg. Intravenous administration of extract reduced the arterial blood pressure (eg. administration of 0.03 mg/kg of aqueous extract of valeriana officinialis changed the blood pressure from 140 ± 5 to 77 ± 10 mmHg, P