Combined Application of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Inhibitors Suppresses Cell Growth and Promotes Apoptosis in Human Lung Cancer Cell Lines

Abstract

PI3K/Akt/mTOR would be an important intracellular signal pathway which has found to be over-activated in neoplasia. Here, the combination effect of LY294002 (PI3K inhibitor) and rapamycine (mTOR inhibitor) has evaluated in different human lung cancer cell lines.