<i>Aspergillus</i> Species and Human Papillomavirus Infections in Epithelial Tumors of Nasal and Paranasal Cavities
| Author | Ali Dehghani Nazhvani | en |
| Author | Ali Farhadi | en |
| Author | Parisa Badiee | en |
| Author | Haleh Keshvari | en |
| Author | Mohammad Javad Ashraf | en |
| Author | Fatemeh Pakdel | en |
| Author | Golnoush Farzinnia | en |
| Orcid | Ali Dehghani Nazhvani [0000-0002-9472-8793] | en |
| Orcid | Ali Farhadi [0000-0002-2272-670X] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: There are diverse lesions originating from the paranasal sinuses and nasal cavity. Tobacco use, alcohol consumption, and malnutrition have been identified to play a role in the development of head and neck carcinomas. Recently, fungi and viruses have been recognized as potential causes of nasal cavity and paranasal tumors. Objectives: This study aimed at specifying the prevalence of Aspergillus and human papillomavirus (HPV) infections in the epithelial tumors of nasal cavity and paranasal sinuses. Methods: In this cross-sectional study, 57 paraffin-embedded tissue samples of malignant and benign lesions of the paranasal sinuses and nasal cavity were evaluated for the presence of Aspergillus and HPV DNA by nested polymerase chain reaction (nPCR) technique with specific primers. Results: Despite the absence of angular hyphae (acute angle) of the fungus on histopathological slides, overall, 10 (17.54%) out of 57 paraffin-embedded samples were found to be positive for Aspergillus species. However, HPV-DNA was not found in any of the samples. Conclusions: Our data suggest that fungal infections (especially aspergillosis) as an etiological factor can be contributed to the development of sinonasal cancer and, therefore, they should be considered in the management of patients with sinonasal cancer. In addition, PCR can provide an alternative to culture-dependent identification methods. | en |
| DOI | https://doi.org/10.5812/ijcm-133155 | en |
| Keyword | <i>Aspergillus</i> | en |
| Keyword | Human Papillomavirus | en |
| Keyword | Nasal Cavity | en |
| Keyword | Nested PCR | en |
| Keyword | Paranasal Sinuses | en |
| Publisher | Brieflands | en |
| Title | <i>Aspergillus</i> Species and Human Papillomavirus Infections in Epithelial Tumors of Nasal and Paranasal Cavities | en |
| Type | Research Article | en |
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