Synthesis and Docking Analysis of New Heterocyclic System N<sup>1</sup>, N<sup>4</sup>-bis (2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor
| Author | Sohrab Ghanei | en |
| Author | Jalil Lari | en |
| Author | Hossein Eshghi | en |
| Author | Mohammad Saadatmandzadeh | en |
| Issued Date | 2016-07-31 | en |
| Abstract | In recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, N1,N4-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological effects. As the inhibitor of AKT1 (RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1), the aforementioned compounds may have implication in preventing complications of cancers. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1895 | en |
| Keyword | AKT1 Inhibitors | en |
| Keyword | Cancer | en |
| Keyword | Docking Analysis | en |
| Keyword | Heterocyclic compound | en |
| Keyword | Quinoline derivatives | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Docking Analysis of New Heterocyclic System N<sup>1</sup>, N<sup>4</sup>-bis (2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor | en |
| Type | Original Article | en |
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