Comparative Proteomics of Sera From HCC Patients With Different Origins

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AuthorJamal Sarvarien
AuthorZahra Mojtahedien
AuthorYasuhiro Kuramitsuen
AuthorMohammad Reza Fattahien
AuthorAbbas Ghaderien
AuthorKazuyuki Nakamuraen
AuthorNasrollah Erfanien
Issued Date2014-01-01en
AbstractBackground: Hepatocellular carcinoma (HCC), a major fatal cancer worldwide, is induced by different etiological factors in the liver. Objectives: To gain insight into serum protein profiling of HCC with different etiologies. Patients and Methods: We subjected the sera of HBV-HCC, HCV-HCC, non-B non-C-HCC patients, and healthy volunteers to two-dimensional gel electrophoresis (2-DE) and liquid chromatography tandem mass spectrometry (LC-MS/MS). Results: We found 30 differentially expressed protein spots (≥ 1.5 fold P < 0.05) between these two analyses; of them 17 protein spots corresponding to 8 proteins were identified by MS. Transthyretin, leucine rich α-2-glycoprotein, and ficolin 3 were differentially expressed between HBV-related HCC and non-B non-C-HCC sera. Moreover, haptoglobin α-2 isoforms were decreased in HCV-HCC compared to non-B non-CHCC. Conclusions: Serum proteome analyses of HCC with different origins showed a differential protein pattern, presumably related to different hepatopathogenesis in liver induced by different agents. Further studies are required to clarify the importance of identified proteins for early diagnosis of HCC with different origins.en
DOIhttps://doi.org/10.5812/hepatmon.13103en
KeywordHepatitis B Virusen
KeywordHepatitis Cen
KeywordCarcinomaen
KeywordHepatocellularen
KeywordElectrophoresisen
KeywordGelen
KeywordTwo-Dimensionalen
KeywordBiological Markersen
PublisherBrieflandsen
TitleComparative Proteomics of Sera From HCC Patients With Different Originsen
TypeResearch Articleen

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