Rho GDP Protein Expression Change and Investigation of ItsEffect on GDP/GTP Cycle in Human Brain Oligodendroglioma

Abstract

Background: Oligodendrogliomas are sub-types of Gliomas with an enriched net of branching capillary. A vast amount of Oligodendroglial (approximately 60-90%) demonstrates a loss of 1p and 19q chromosomes, and their response to radio and chemotherapy treatments are considerably more favorable and less aggressive. Rho GDP inhibitor is a protein which controls the activity and distribution of GTPase in cells. In cancer cells with 1pLOH deletion, Rho GDP inhibitor protein can be anti-apoptotic. Here understanding of molecular diagnosis of Oligodendroglioma tumors is investigated via proteomic tools.