Determination of Serum Calprotectin, Heparin-Binding Protein, and Some Inflammatory Factors in Patients with COVID-19
| Author | Rajab Mardani | en |
| Author | Seyed Dawood Mousavi-Nasab | en |
| Author | Maryam Shahali | en |
| Author | Mohammad Javad Hossein Tehrani | en |
| Author | Nayebali Ahmadi | en |
| Author | Fatemeh Zali | en |
| Author | Iraj Khodadadi | en |
| Orcid | Rajab Mardani [0000-0001-7730-3040] | en |
| Orcid | Nayebali Ahmadi [0000-0003-2243-8276] | en |
| Issued Date | 2023-10-31 | en |
| Abstract | Background: Among the serum biomarkers of infectious diseases, calprotectin and heparin-binding protein (HBP) seem to be of clinical and diagnostic value in patients with COVID-19. Objectives: This study aimed to investigate the serum levels of calprotectin, HBP, and some other inflammatory markers in COVID-19 patients. Methods: In this case-control study, serum samples of 35 outpatients with COVID-19 and 35 healthy individuals were collected, and the levels of calprotectin, HBP, C-reactive protein (CRP), ferritin (FERR), as well as platelet (PLT) and neutrophil (NEU) counts and LDH activity, were determined. Results: At first, SARS-CoV2 viral RNA was detected in the pharyngeal swab specimens of COVID-19 patients. Calprotectin, FERR, and CRP levels, LDH activity, and PLT and NEU counts were found to be significantly higher in COVID-19 patients compared with controls (P < 0.05), whereas no statistically significant difference was observed in HBP level (P > 0.05). Serum calprotectin showed a significant correlation with CRP and FERR levels, LDH activity, and NEU count (P < 0.001). Conclusions: Our findings showed that an increment in serum calprotectin level, together with increased CRP levels, might be a promising indicator of SARS-CoV2 infection. | en |
| DOI | https://doi.org/10.5812/archcid-139430 | en |
| Keyword | Heparin-Binding Protein | en |
| Keyword | Calprotectin | en |
| Keyword | COVID-19 | en |
| Keyword | C-reactive Protein | en |
| Publisher | Brieflands | en |
| Title | Determination of Serum Calprotectin, Heparin-Binding Protein, and Some Inflammatory Factors in Patients with COVID-19 | en |
| Type | Research Article | en |