The Correlation Between Uric Acid Level and Right Heart Catheterization Findings in Pulmonary Hypertension

Abstract

Background: Pulmonary hypertension is a rare and fatal disease and several methods are available for its risk stratification. Right heart catheterization is gold standard tool for this target but this method is invasive and expensive. Serum uric acid level is a controversial method for this aim. Objectives: This paper aims to discover a correlation between serum uric acid level and severity of pulmonary hypertension based on right heart catheterization. Methods: Uric acid level was measured in 128 pulmonary hypertension patients who had undergone right heart catheterization. Then, the correlations between uric acid level and right heart catheterization findings as well as pulmonary hypertension severity were assessed. Results: The correlations between serum uric acid level and CI (P = 0.019), DAP (P = 0.032), MAP (P = 0.027), RAP (P = 0.002), SPAP (P = 0.015), MPAP (P = 0.035), PPPA (P = 0.011), SO2S (P = 0.005), MVO2S (P = 0.004) are significant. A positive correlation was found between serum uric acid level and pulmonary hypertension risk based on RAP (P = 0.006) and MVO2S (P = 0.022). Conclusions: It was found that the serum uric acid level is significantly correlated with some parameters of right heart catheterization including CI, DAP, MAP, SPAP, MPAP, PPPA, especially RAP, SO2S and MVO2S. Also uric acid level is significantly correlated with severity of pulmonary hypertension based on RAP and MVO2S and the level is increased in high risk ranked patients.