Is There any Correlation Between Pulmonary and Coronary Involvement in Diabetic Patients?
| Author | Mahmoud Parham | en |
| Author | Mohammad Aghaali | en |
| Author | Seyed Hassan Adeli | en |
| Author | Ahmad Reza Bagheri | en |
| Author | Masoud Sadeghi | en |
| Author | Akram Asghari | en |
| Orcid | Mahmoud Parham [0000-0002-6211-077X] | en |
| Orcid | Mohammad Aghaali [0000-0003-3417-1580] | en |
| Orcid | Seyed Hassan Adeli [0000-0001-5970-7551] | en |
| Orcid | Ahmad Reza Bagheri [0000-0002-3759-3511] | en |
| Orcid | Akram Asghari [0000-0001-6948-2675] | en |
| Issued Date | 2025-07-31 | en |
| Abstract | Background: Diabetes is a major global health issue, affecting over 8.5% of adults worldwide and significantly increasing the risk of cardiovascular diseases (CVDs). However, the association between diabetes-related macrovascular complications, such as coronary artery disease (CAD), and pulmonary function remains unclear. Objectives: The present study was designed to investigate the association between obstructive and restrictive lung patterns and the severity of coronary artery involvement. Methods: A cross-sectional study was conducted at Shahid Beheshti Hospital, Qom, Iran, between April 2019 and August 2021. A total of 211 diabetic patients who underwent coronary angiography (CAG) were selected. They were divided into two groups: Sixty-nine patients in group 1 (non-significant CAD) and 142 patients in group 2 (significant CAD). Spirometry was performed to assess forced expiratory volume (FEV), forced vital capacity (FVC), and FEV/FVC ratio, with values adjusted for age and sex in the two groups. Results: Among the 211 participants, 142 (67.3%) exhibited significant coronary artery involvement. Comparative analysis revealed no statistically significant differences in spirometric parameters [forced expiratory volume in one second (FEV1), FVC, FEV1/FVC ratio] between the groups. Notably, advancing age demonstrated a significant negative correlation with both FEF50% (β = -0.32, P < 0.01) and FVC values (β = -0.28, P < 0.05). Multivariate regression analysis identified inverse relationships between age and peak expiratory flow (PEF; β = -0.41, P < 0.001), HbA1C levels and PEF (β = -0.23, P < 0.05). Additionally, sex emerged as a significant modifier of %FEV1/FVC (β = 0.19, P < 0.05), with female participants showing lower ratios. Conclusions: This study failed to find an association between spirometry findings and coronary artery involvement. However, a significant relationship between small airway involvement and glycemic control was observed. | en |
| DOI | https://doi.org/10.5812/ijem-160600 | en |
| URI | https://brieflands.com/journals/ijem/articles/160600 | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | Coronary Artery Disease (CAD) | en |
| Keyword | Macrovascular Complications | en |
| Keyword | Spirometry | en |
| Keyword | Age-Related Changes | en |
| Publisher | Brieflands | en |
| Title | Is There any Correlation Between Pulmonary and Coronary Involvement in Diabetic Patients? | en |
| Type | Research Article | en |
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