Physicochemical Evaluation of Lyophilized Formulation of <i>p</i>-SCN-Bn-DOTA- and <i>p</i>-SCN-Bn-DTPA-rituximab for NHL Radio Immunotherapy
| Author | Darinka Gjorgieva Ackova | en |
| Author | Katarina Smilkov | en |
| Author | Emilija Janevik-Ivanovska | en |
| Issued Date | 2016-07-31 | en |
| Abstract | Radioimmunotherapy (RIT) of Non-Hodgkin’s lymphoma (NHL) is said to be more advantageous compared to unlabelled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb radio immunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic profile at the same time. This study was conducted to evaluate prepared lyophilized formulations of two rituximab immune conjugates, intended for immediate Lu-177 labeling, for imaging and therapy. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1878 | en |
| Keyword | Rituximab | en |
| Keyword | Lyophilized formulation | en |
| Keyword | <i>p</i>-SCN-Bn-DOTA | en |
| Keyword | <i>p</i>-SCN-Bn-DTPA | en |
| Publisher | Brieflands | en |
| Title | Physicochemical Evaluation of Lyophilized Formulation of <i>p</i>-SCN-Bn-DOTA- and <i>p</i>-SCN-Bn-DTPA-rituximab for NHL Radio Immunotherapy | en |
| Type | Original Article | en |
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